5-(3-(3-(2-cyano-2-ethoxycarbonylvinyl)-2,5-dimethyl-1H-pyrrol-1-yl)phenyl)-1H-tetrazole

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Chemical Name:5-(3-(3-(2-cyano-2-ethoxycarbonylvinyl)-2,5-dimethyl-1H-pyrrol-1-yl)phenyl)-1H-tetrazole
CAS No.:1347754-89-5
Molecular Formula:C₁₉H₁₈N₆O₂
Molecular Weight:362.391
Hs Code.:

Synonyms:5-(3-(3-(2-cyano-2-ethoxycarbonylvinyl)-2,5-dimethyl-1H-pyrrol-1-yl)phenyl)-1H-tetrazole

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Chemical Property of 5-(3-(3-(2-cyano-2-ethoxycarbonylvinyl)-2,5-dimethyl-1H-pyrrol-1-yl)phenyl)-1H-tetrazole

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Technology Process of 5-(3-(3-(2-cyano-2-ethoxycarbonylvinyl)-2,5-dimethyl-1H-pyrrol-1-yl)phenyl)-1H-tetrazole

There total 5 articles about 5-(3-(3-(2-cyano-2-ethoxycarbonylvinyl)-2,5-dimethyl-1H-pyrrol-1-yl)phenyl)-1H-tetrazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1236915-86-8
2,5-dimethyl-1H-pyrrole-1-(3-(1H-tetrazol-5-yl)phenyl)-3-carbaldehyde

: 105-56-6
ethyl 2-cyanoacetate

: 1347754-89-5
5-(3-(3-(2-cyano-2-ethoxycarbonylvinyl)-2,5-dimethyl-1H-pyrrol-1-yl)phenyl)-1H-tetrazole

Guidance literature:: With piperidine; In ethanol; for 5h; Reflux;
DOI:10.1016/j.bmc.2011.09.047

Reference yield:

: 204142-42-7
3-(2,5-dimethyl-1H-pyrrol-1-yl)benzonitrile

: 1347754-89-5
5-(3-(3-(2-cyano-2-ethoxycarbonylvinyl)-2,5-dimethyl-1H-pyrrol-1-yl)phenyl)-1H-tetrazole

Guidance literature:: Multi-step reaction with 3 steps

1.1: trichlorophosphate / 0.5 h / 10 °C

1.2: 2.33 h / 10 - 20 °C

1.3: 0.5 h / pH 9 - 10 / Cooling with ice; Reflux

2.1: sodium azide; triethylamine hydrochloride / water; toluene / 12 h / Reflux

3.1: piperidine / ethanol / 5 h / Reflux

With piperidine; sodium azide; triethylamine hydrochloride; trichlorophosphate; In ethanol; water; toluene; 1.2: Vilsmeier-Haack reaction / 3.1: Knoevenagel condensation;
DOI:10.1016/j.bmc.2011.09.047

Reference yield:

: 937653-09-3
3-(2,5-dimethyl-3-formyl-1H-pyrrol-1-yl)benzonitrile

: 1347754-89-5
5-(3-(3-(2-cyano-2-ethoxycarbonylvinyl)-2,5-dimethyl-1H-pyrrol-1-yl)phenyl)-1H-tetrazole

Guidance literature:: Multi-step reaction with 2 steps

1: sodium azide; triethylamine hydrochloride / water; toluene / 12 h / Reflux

2: piperidine / ethanol / 5 h / Reflux

With piperidine; sodium azide; triethylamine hydrochloride; In ethanol; water; toluene; 2: Knoevenagel condensation;
DOI:10.1016/j.bmc.2011.09.047