2-(7-{[N-({4-[((2R)-2-amino-4-phenylbutanoylaminooxy)methyl]phenyl}methyl)carbamoyl]methyl}-1,4,7,10-tetraaza-4,10-bis(carboxymethyl)cyclododecyl)acetic acid trifluoroacetic acid salt

Base Information

Chemical Name:2-(7-{[N-({4-[((2R)-2-amino-4-phenylbutanoylaminooxy)methyl]phenyl}methyl)carbamoyl]methyl}-1,4,7,10-tetraaza-4,10-bis(carboxymethyl)cyclododecyl)acetic acid trifluoroacetic acid salt
CAS No.:1173156-02-9
Molecular Formula:C₂HF₃O₂*C₃₄H₄₉N₇O₉
Molecular Weight:813.829
Hs Code.:

2-(7-{[N-({4-[((2R)-2-amino-4-phenylbutanoylaminooxy)methyl]phenyl}methyl)carbamoyl]methyl}-1,4,7,10-tetraaza-4,10-bis(carboxymethyl)cyclododecyl)acetic acid trifluoroacetic acid salt

Synonyms:2-(7-{[N-({4-[((2R)-2-amino-4-phenylbutanoylaminooxy)methyl]phenyl}methyl)carbamoyl]methyl}-1,4,7,10-tetraaza-4,10-bis(carboxymethyl)cyclododecyl)acetic acid trifluoroacetic acid salt

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Chemical Property of 2-(7-{[N-({4-[((2R)-2-amino-4-phenylbutanoylaminooxy)methyl]phenyl}methyl)carbamoyl]methyl}-1,4,7,10-tetraaza-4,10-bis(carboxymethyl)cyclododecyl)acetic acid trifluoroacetic acid salt

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Technology Process of 2-(7-{[N-({4-[((2R)-2-amino-4-phenylbutanoylaminooxy)methyl]phenyl}methyl)carbamoyl]methyl}-1,4,7,10-tetraaza-4,10-bis(carboxymethyl)cyclododecyl)acetic acid trifluoroacetic acid salt

There total 13 articles about 2-(7-{[N-({4-[((2R)-2-amino-4-phenylbutanoylaminooxy)methyl]phenyl}methyl)carbamoyl]methyl}-1,4,7,10-tetraaza-4,10-bis(carboxymethyl)cyclododecyl)acetic acid trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 26.1%

: 1173156-01-8
C₃₄H₄₉N₇O₉

: 76-05-1
trifluoroacetic acid

: 1173156-02-9
2-(7-{[N-({4-[((2R)-2-amino-4-phenylbutanoylaminooxy)methyl]phenyl}methyl)carbamoyl]methyl}-1,4,7,10-tetraaza-4,10-bis(carboxymethyl)cyclododecyl)acetic acid trifluoroacetic acid salt

Guidance literature:: In water; acetonitrile;

Reference yield:

: 1173157-72-6
C₅₁H₈₁N₇O₁₁

: 76-05-1
trifluoroacetic acid

: 1173156-02-9
2-(7-{[N-({4-[((2R)-2-amino-4-phenylbutanoylaminooxy)methyl]phenyl}methyl)carbamoyl]methyl}-1,4,7,10-tetraaza-4,10-bis(carboxymethyl)cyclododecyl)acetic acid trifluoroacetic acid salt

Guidance literature:: C₅₁H₈₁N₇O₁₁; With hydrogenchloride; In 1,4-dioxane; water; at 22 ℃; for 16h;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 6232-11-7
methyl 4-(aminomethyl)benzoate hydrochloride

: 1173156-02-9
2-(7-{[N-({4-[((2R)-2-amino-4-phenylbutanoylaminooxy)methyl]phenyl}methyl)carbamoyl]methyl}-1,4,7,10-tetraaza-4,10-bis(carboxymethyl)cyclododecyl)acetic acid trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 1 h / 0 °C

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 0.5 h / 0 °C

2.2: 0.25 h

3.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 0.58 h / 0 - 22 °C

4.1: potassium carbonate / N,N-dimethyl-formamide / 13 h / 0 - 22 °C

5.1: diethylamine / trisodium tris(3-sulfophenyl)phosphine; palladium diacetate / acetonitrile; water / 0.5 h / 22 °C

6.1: N-ethyl-N,N-diisopropylamine; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h / 22 °C

6.2: 3.25 h

7.1: hydrogenchloride / 1,4-dioxane; water / 16 h / 22 °C

With hydrogenchloride; lithium aluminium tetrahydride; carbon tetrabromide; potassium carbonate; benzotriazol-1-ol; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; diethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trisodium tris(3-sulfophenyl)phosphine; palladium diacetate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; N,N-dimethyl-formamide; acetonitrile;