2-((2-chloro-4-(6-(5-((4-methyl-1,4-azaphosphino-1-yl)methyl)furan-2-yl)quinazolin-4-ylamino)phenoxy)methyl)pyridine 1-oxide

Base Information

Chemical Name:2-((2-chloro-4-(6-(5-((4-methyl-1,4-azaphosphino-1-yl)methyl)furan-2-yl)quinazolin-4-ylamino)phenoxy)methyl)pyridine 1-oxide
CAS No.:1260402-04-7
Molecular Formula:C₃₀H₂₉ClN₅O₄P
Molecular Weight:590.018
Hs Code.:

Synonyms:2-((2-chloro-4-(6-(5-((4-methyl-1,4-azaphosphino-1-yl)methyl)furan-2-yl)quinazolin-4-ylamino)phenoxy)methyl)pyridine 1-oxide

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Chemical Property of 2-((2-chloro-4-(6-(5-((4-methyl-1,4-azaphosphino-1-yl)methyl)furan-2-yl)quinazolin-4-ylamino)phenoxy)methyl)pyridine 1-oxide

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Technology Process of 2-((2-chloro-4-(6-(5-((4-methyl-1,4-azaphosphino-1-yl)methyl)furan-2-yl)quinazolin-4-ylamino)phenoxy)methyl)pyridine 1-oxide

There total 2 articles about 2-((2-chloro-4-(6-(5-((4-methyl-1,4-azaphosphino-1-yl)methyl)furan-2-yl)quinazolin-4-ylamino)phenoxy)methyl)pyridine 1-oxide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 945459-80-3
4-methyl-1,4-azaphosphinane 4-oxide hydrochloride

: 1260402-53-6
2-((2-chloro-4-(6-(5-formylfuran-2-yl)quinazolin-4-ylamino)phenoxy)methyl)pyridine 1-oxide

: 1260402-04-7
2-((2-chloro-4-(6-(5-((4-methyl-1,4-azaphosphino-1-yl)methyl)furan-2-yl)quinazolin-4-ylamino)phenoxy)methyl)pyridine 1-oxide

Guidance literature:: 4-methyl-1,4-azaphosphinane 4-oxide hydrochloride; 2-((2-chloro-4-(6-(5-formylfuran-2-yl)quinazolin-4-ylamino)phenoxy)methyl)pyridine 1-oxide; With acetic acid; N-ethyl-N,N-diisopropylamine; In 1,1-dichloroethane; for 0.5h;

With sodium tris(acetoxy)borohydride; In 1,1-dichloroethane;

With sodium hydroxide; In 1,1-dichloroethane;

Reference yield:

: 945459-79-0
1-benzyl-4-methyl-1,4-azaphosphinane 4-oxide

: 1260402-04-7
2-((2-chloro-4-(6-(5-((4-methyl-1,4-azaphosphino-1-yl)methyl)furan-2-yl)quinazolin-4-ylamino)phenoxy)methyl)pyridine 1-oxide

Guidance literature:: Multi-step reaction with 2 steps

1: hydrogenchloride; hydrogen / palladium 10% on activated carbon / water; methanol / 24 h / 3102.97 Torr

2: N-ethyl-N,N-diisopropylamine; acetic acid / 1,1-dichloroethane / 0.5 h

With hydrogenchloride; hydrogen; acetic acid; N-ethyl-N,N-diisopropylamine; palladium 10% on activated carbon; In methanol; 1,1-dichloroethane; water;