(4R,5R)-4,5-Bis-[(R)-2-benzyloxy-1-(4-fluoro-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolane

Base Information

• Chemical Name: (4R,5R)-4,5-Bis-[(R)-2-benzyloxy-1-(4-fluoro-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolane
• CAS No.: 628690-07-3
• Molecular Formula: C₃₇H₄₀F₂O₆
• Molecular Weight: 618.718

Synonyms:(4R,5R)-4,5-Bis-[(R)-2-benzyloxy-1-(4-fluoro-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolane

Chemical Property of (4R,5R)-4,5-Bis-[(R)-2-benzyloxy-1-(4-fluoro-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolane

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Technology Process of (4R,5R)-4,5-Bis-[(R)-2-benzyloxy-1-(4-fluoro-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolane

There total 2 articles about (4R,5R)-4,5-Bis-[(R)-2-benzyloxy-1-(4-fluoro-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

1,6-di-O-benzyl-3,4-O-methylethylidene-D-mannitol (142285-64-1) + 4-Fluorobenzyl bromide (459-46-1) → (4R,5R)-4,5-Bis-[(R)-2-benzyloxy-1-(4-fluoro-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolane (628690-07-3)

Guidance literature:

With sodium hydride; In N,N-dimethyl-formamide;

DOI:10.1016/S0960-894X(03)00677-2

Reference yield:

3,4-di-O-isopropylidene-D-mannitol (3969-84-4) → (4R,5R)-4,5-Bis-[(R)-2-benzyloxy-1-(4-fluoro-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolane (628690-07-3)

Guidance literature:

Multi-step reaction with 2 steps

1.1: Bu₂SnO / toluene / Heating

1.2: 82 percent / CsF

2.1: 88 percent / NaH / dimethylformamide

With sodium hydride; di(n-butyl)tin oxide; In N,N-dimethyl-formamide; toluene;

DOI:10.1016/S0960-894X(03)00677-2

Reference yield: 95.0%

(4R,5R)-4,5-Bis-[(R)-2-benzyloxy-1-(4-fluoro-benzyloxy)-ethyl]-2,2-dimethyl-[1,3]dioxolane (628690-07-3) → 1,6-di-O-benzyl-2,5-di-O-(4-fluorobenzyl)-D-mannitol

Guidance literature:

With hydrogenchloride; In methanol;

DOI:10.1016/S0960-894X(03)00677-2

upstream raw materials:

1,6-di-O-benzyl-3,4-O-methylethylidene-D-mannitol

4-Fluorobenzyl bromide

3,4-di-O-isopropylidene-D-mannitol

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