(4S,4aS,8aS)-4,4a-epoxy-3-hydroxy-8a-methyl-1,4,4a,5,6,7,8,8a-octahydronaphthalene-2-N-phenylcarboxamide

Base Information

Chemical Name:(4S,4aS,8aS)-4,4a-epoxy-3-hydroxy-8a-methyl-1,4,4a,5,6,7,8,8a-octahydronaphthalene-2-N-phenylcarboxamide
CAS No.:168774-82-1
Molecular Formula:C₁₈H₂₁NO₃
Molecular Weight:299.37
Hs Code.:

Synonyms:(4S,4aS,8aS)-4,4a-epoxy-3-hydroxy-8a-methyl-1,4,4a,5,6,7,8,8a-octahydronaphthalene-2-N-phenylcarboxamide

Suppliers and Price of (4S,4aS,8aS)-4,4a-epoxy-3-hydroxy-8a-methyl-1,4,4a,5,6,7,8,8a-octahydronaphthalene-2-N-phenylcarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S,4aS,8aS)-4,4a-epoxy-3-hydroxy-8a-methyl-1,4,4a,5,6,7,8,8a-octahydronaphthalene-2-N-phenylcarboxamide

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of (4S,4aS,8aS)-4,4a-epoxy-3-hydroxy-8a-methyl-1,4,4a,5,6,7,8,8a-octahydronaphthalene-2-N-phenylcarboxamide

There total 5 articles about (4S,4aS,8aS)-4,4a-epoxy-3-hydroxy-8a-methyl-1,4,4a,5,6,7,8,8a-octahydronaphthalene-2-N-phenylcarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 168775-02-8
Acetic acid (1aR,4aS,8aS)-3-(acetyl-phenyl-carbamoyl)-4a-methyl-4,4a,5,6,7,8-hexahydro-1aH-1-oxa-cyclopropa[d]naphthalen-2-yl ester

: 168774-82-1
(4S,4aS,8aS)-4,4a-epoxy-3-hydroxy-8a-methyl-1,4,4a,5,6,7,8,8a-octahydronaphthalene-2-N-phenylcarboxamide

Guidance literature:: With sodium hydrogencarbonate; In methanol; for 2h; Yield given; Heating;
DOI:10.1021/jm00017a003

Reference yield:

: 4087-39-2
(S)-(+)-4,4a,5,6,7,8-hexahydro-4a-methyl-2(3H)-naphthalenone

: 168774-82-1
(4S,4aS,8aS)-4,4a-epoxy-3-hydroxy-8a-methyl-1,4,4a,5,6,7,8,8a-octahydronaphthalene-2-N-phenylcarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1: 1.) LDA / 1.) THF, -78 deg C, 30 min, 2.) THF, a) -78 deg C, 20 min, b) RT

2: 39 percent / pyridine / 14 h / 140 °C

3: 900 mg / pyridine / Ambient temperature

4: 520 mg / m-CPBA / CH₂Cl₂

5: aq. NaHCO₃ / methanol / 2 h / Heating

With pyridine; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; lithium diisopropyl amide; In methanol; dichloromethane;
DOI:10.1021/jm00017a003

Reference yield:

: 168774-80-9
Trimethyl-((S)-4a-methyl-4,4a,5,6,7,8-hexahydro-naphthalen-2-yloxy)-silane

: 168774-82-1
(4S,4aS,8aS)-4,4a-epoxy-3-hydroxy-8a-methyl-1,4,4a,5,6,7,8,8a-octahydronaphthalene-2-N-phenylcarboxamide

Guidance literature:: Multi-step reaction with 4 steps

1: 39 percent / pyridine / 14 h / 140 °C

2: 900 mg / pyridine / Ambient temperature

3: 520 mg / m-CPBA / CH₂Cl₂

4: aq. NaHCO₃ / methanol / 2 h / Heating

With pyridine; sodium hydrogencarbonate; 3-chloro-benzenecarboperoxoic acid; In methanol; dichloromethane;
DOI:10.1021/jm00017a003