3-(4-chlorophenyl)-3-methylpentanedioic acid

Base Information

Chemical Name:3-(4-chlorophenyl)-3-methylpentanedioic acid
CAS No.:91393-73-6
Molecular Formula:C₁₂H₁₃ClO₄
Molecular Weight:256.686
Hs Code.:

Synonyms:3-(4-chlorophenyl)-3-methylpentanedioic acid

Suppliers and Price of 3-(4-chlorophenyl)-3-methylpentanedioic acid

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Total 3 raw suppliers

Chemical Property of 3-(4-chlorophenyl)-3-methylpentanedioic acid

Chemical Property:

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Technology Process of 3-(4-chlorophenyl)-3-methylpentanedioic acid

There total 4 articles about 3-(4-chlorophenyl)-3-methylpentanedioic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

: 92161-82-5
2,4-dicyano-3-methyl-3-(p-chlorophenyl)glutarimide

: 91393-73-6
3-(4-chlorophenyl)-3-methylpentanedioic acid

Guidance literature:: With sulfuric acid; acetic acid; at 160 ℃; for 96h;
DOI:10.1002/jhet.5570330122

Reference yield:

: 99-91-2
para-chloroacetophenone

: 91393-73-6
3-(4-chlorophenyl)-3-methylpentanedioic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 38 percent / NH₄OAc; AcOH / toluene / Heating

2: 87 percent / EtONa / ethanol / 4 h / 20 °C

3: 48 percent / aq. H₂SO₄; AcOH / 40 h / Heating

With sulfuric acid; ammonium acetate; sodium ethanolate; acetic acid; In ethanol; toluene; 1: Knoevenagel condensation / 2: Michael addition / 3: Hydrolysis;
DOI:10.1021/jm990957g

Reference yield:

: 17277-51-9
3-(4-Chlorophenyl)-2-cyano-but-2-enoic acid ethyl ester

: 91393-73-6
3-(4-chlorophenyl)-3-methylpentanedioic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 82 percent / NaOEt / ethanol / 0.33 h

2: 84 percent / 50percent aq. H₂SO₄, AcOH / 96 h / 160 °C

With sulfuric acid; sodium ethanolate; acetic acid; In ethanol;
DOI:10.1002/jhet.5570330122