diethyl 2-[[[1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridin-5-yl]amino]methylene]propanedioate

Base Information

Chemical Name:diethyl 2-[[[1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridin-5-yl]amino]methylene]propanedioate
CAS No.:1401447-79-7
Molecular Formula:C₂₂H₂₃N₃O₆S
Molecular Weight:457.507
Hs Code.:

Synonyms:diethyl 2-[[[1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridin-5-yl]amino]methylene]propanedioate

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Chemical Property of diethyl 2-[[[1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridin-5-yl]amino]methylene]propanedioate

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Technology Process of diethyl 2-[[[1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridin-5-yl]amino]methylene]propanedioate

There total 6 articles about diethyl 2-[[[1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridin-5-yl]amino]methylene]propanedioate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.0%

: 1146215-17-9
1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridine-5-amine

: 40131-09-7
diethyl methoxymethylenemalonate

: 1401447-79-7
diethyl 2-[[[1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridin-5-yl]amino]methylene]propanedioate

Guidance literature:: at 120 - 130 ℃;

Reference yield:

: 101083-92-5
5-nitro-1H-pyrrolo[2,3-b]pyridine

: 1401447-79-7
diethyl 2-[[[1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridin-5-yl]amino]methylene]propanedioate

Guidance literature:: Multi-step reaction with 3 steps

1: sodium hydroxide / water; acetone / 0 °C

2: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 20 °C

3: 120 - 130 °C

With hydrogen; sodium hydroxide; palladium 10% on activated carbon; In methanol; dichloromethane; water; acetone;

Reference yield:

: 4214-76-0,67476-67-9
5-nitro-pyridin-2-ylamine

: 1401447-79-7
diethyl 2-[[[1-(p-tolylsulfonyl)pyrrolo[2,3-b]pyridin-5-yl]amino]methylene]propanedioate

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid; potassium metaperiodate / 100 °C

1.2: 2.5 h / Heating

1.3: 20 °C

2.1: triethylamine / copper(l) iodide; bis-triphenylphosphine-palladium(II) chloride / tetrahydrofuran; 2-ethylbutanamide / 2 h / Inert atmosphere

3.1: copper(l) iodide / N,N-dimethyl-formamide / 2 h / Inert atmosphere

4.1: sodium hydroxide / water; acetone / 0 °C

5.1: hydrogen / palladium 10% on activated carbon / dichloromethane; methanol / 20 °C

6.1: 120 - 130 °C

With potassium metaperiodate; sulfuric acid; hydrogen; triethylamine; sodium hydroxide; bis-triphenylphosphine-palladium(II) chloride; copper(l) iodide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; dichloromethane; 2-ethylbutanamide; water; N,N-dimethyl-formamide; acetone;