Technology Process of (S)-2-((R)-5-Carboxymethyl-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylamino)-4-(tetrahydro-pyran-4-yl)-butyric acid
There total 1 articles about (S)-2-((R)-5-Carboxymethyl-4-oxo-2,3,4,5-tetrahydro-benzo[b][1,4]thiazepin-3-ylamino)-4-(tetrahydro-pyran-4-yl)-butyric acid which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
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Multi-step reaction with 6 steps
1: benzene / 1 h / Heating
2: H2 / 10 percent Pd-C / ethanol / Ambient temperature
3: 1) NaOEt; 2) H2SO4, LiCl / 1) EtOH, 70 deg C, 60 min; 2) DMSO, 140 deg C, 2.5 h
4: 35 percent / NaBH3CN, molecular sieves 4 Angstroem / acetic acid; ethanol / Ambient temperature
5: 89 percent / 5 N HCl / ethyl acetate / Ambient temperature
6: 98 percent / 1 N NaOH / ethanol / Ambient temperature
With
hydrogenchloride; sodium hydroxide; 4 A molecular sieve; sulfuric acid; hydrogen; sodium ethanolate; sodium cyanoborohydride; lithium chloride;
palladium on activated charcoal;
In
ethanol; acetic acid; ethyl acetate; benzene;
DOI:10.1248/cpb.34.1128