Technology Process of (8R,8aR)-8-(benzyloxy)-5-indolizidinone
There total 4 articles about (8R,8aR)-8-(benzyloxy)-5-indolizidinone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
palladium 10% on activated carbon; ammonium acetate; hydrogen;
In
ethyl acetate;
at 20 ℃;
for 24h;
under 760.051 Torr;
optical yield given as %de;
diastereoselective reaction;
DOI:10.1007/s11426-011-4256-4
- Guidance literature:
-
Multi-step reaction with 2 steps
1: silica gel / dichloromethane / 3 h / 25 °C
2: palladium 10% on activated carbon; ammonium acetate; hydrogen / ethyl acetate / 24 h / 20 °C / 760.05 Torr
With
palladium 10% on activated carbon; ammonium acetate; hydrogen; silica gel;
In
dichloromethane; ethyl acetate;
DOI:10.1007/s11426-011-4256-4
- Guidance literature:
-
Multi-step reaction with 3 steps
1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 35 °C
2: silica gel / dichloromethane / 3 h / 25 °C
3: palladium 10% on activated carbon; ammonium acetate; hydrogen / ethyl acetate / 24 h / 20 °C / 760.05 Torr
With
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; palladium 10% on activated carbon; ammonium acetate; hydrogen; silica gel;
In
dichloromethane; ethyl acetate;
DOI:10.1007/s11426-011-4256-4
