10-methyl-1-oxo-2-phenylsulfonyl-1,2,3,10-tetrahydroazepino[3,4-b]indol-5-yl trifluoromethanesulfonate

Base Information

Chemical Name:10-methyl-1-oxo-2-phenylsulfonyl-1,2,3,10-tetrahydroazepino[3,4-b]indol-5-yl trifluoromethanesulfonate
CAS No.:292150-61-9
Molecular Formula:C₂₀H₁₅F₃N₂O₆S₂
Molecular Weight:500.476
Hs Code.:

Synonyms:10-methyl-1-oxo-2-phenylsulfonyl-1,2,3,10-tetrahydroazepino[3,4-b]indol-5-yl trifluoromethanesulfonate

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Chemical Property of 10-methyl-1-oxo-2-phenylsulfonyl-1,2,3,10-tetrahydroazepino[3,4-b]indol-5-yl trifluoromethanesulfonate

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Technology Process of 10-methyl-1-oxo-2-phenylsulfonyl-1,2,3,10-tetrahydroazepino[3,4-b]indol-5-yl trifluoromethanesulfonate

There total 6 articles about 10-methyl-1-oxo-2-phenylsulfonyl-1,2,3,10-tetrahydroazepino[3,4-b]indol-5-yl trifluoromethanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 292150-68-6
10-methyl-2-phenylsulfonyl-1,2,3,4,5,10-hexahydroazepino[3,4-b]indole-1,5-dione

: 292150-61-9
10-methyl-1-oxo-2-phenylsulfonyl-1,2,3,10-tetrahydroazepino[3,4-b]indol-5-yl trifluoromethanesulfonate

Guidance literature:: With sodium carbonate; In dichloromethane; at 20 ℃; for 24h;
DOI:10.1016/S0040-4020(00)00374-4

Reference yield:

Indole-2-carboxylic acid: 1477-50-5,1228050-17-6
Indole-2-carboxylic acid

: 292150-61-9
10-methyl-1-oxo-2-phenylsulfonyl-1,2,3,10-tetrahydroazepino[3,4-b]indol-5-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 6 steps

1: 95 percent / DMAP; EDCI / CH₂Cl₂ / 24 h / 0 - 20 °C

2: 90 percent / K₂CO₃ / acetonitrile / 24 h / Heating

3: 96 percent / LiOH / ethanol / 18 h / 20 °C

4: 86 percent / PPA; P₂O₅ / 1 h / 110 °C

5: 90 percent / NaH / dimethylformamide / 1 h / 0 °C

6: 95 percent / Na₂CO₃ / CH₂Cl₂ / 24 h / 20 °C

With dmap; lithium hydroxide; phosphorus pentoxide; sodium hydride; sodium carbonate; potassium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile; 1: Condensation / 2: Methylation / 3: Hydrolysis / 4: Cyclization / 5: Condensation / 6: Condensation;
DOI:10.1016/S0040-4020(00)00374-4

Reference yield:

: 68724-80-1
3-{[(1-methyl)-1H-2-indolylcarbonyl]amino}propanoic acid

: 292150-61-9
10-methyl-1-oxo-2-phenylsulfonyl-1,2,3,10-tetrahydroazepino[3,4-b]indol-5-yl trifluoromethanesulfonate

Guidance literature:: Multi-step reaction with 3 steps

1: 86 percent / PPA; P₂O₅ / 1 h / 110 °C

2: 90 percent / NaH / dimethylformamide / 1 h / 0 °C

3: 95 percent / Na₂CO₃ / CH₂Cl₂ / 24 h / 20 °C

With phosphorus pentoxide; sodium hydride; sodium carbonate; In dichloromethane; N,N-dimethyl-formamide; 1: Cyclization / 2: Condensation / 3: Condensation;
DOI:10.1016/S0040-4020(00)00374-4