(2S,5R)-2-((S)-2-Benzenesulfonyl-1-phenyl-ethyl)-3,6-diethoxy-5-isopropyl-2,5-dihydro-pyrazine

Base Information

• Chemical Name: (2S,5R)-2-((S)-2-Benzenesulfonyl-1-phenyl-ethyl)-3,6-diethoxy-5-isopropyl-2,5-dihydro-pyrazine
• CAS No.: 170899-20-4
• Molecular Formula: C₂₅H₃₂N₂O₄S
• Molecular Weight: 456.606
• Mol file: 170899-20-4.mol

Synonyms:(2S,5R)-2-((S)-2-Benzenesulfonyl-1-phenyl-ethyl)-3,6-diethoxy-5-isopropyl-2,5-dihydro-pyrazine

Chemical Property of (2S,5R)-2-((S)-2-Benzenesulfonyl-1-phenyl-ethyl)-3,6-diethoxy-5-isopropyl-2,5-dihydro-pyrazine

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of (2S,5R)-2-((S)-2-Benzenesulfonyl-1-phenyl-ethyl)-3,6-diethoxy-5-isopropyl-2,5-dihydro-pyrazine

There total 2 articles about (2S,5R)-2-((S)-2-Benzenesulfonyl-1-phenyl-ethyl)-3,6-diethoxy-5-isopropyl-2,5-dihydro-pyrazine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

phenyl styryl sulfone (16212-06-9) + C11H19N2O2(1-)*Li(1+) → (2S,5R)-2-((R)-2-Benzenesulfonyl-1-phenyl-ethyl)-3,6-diethoxy-5-isopropyl-2,5-dihydro-pyrazine (170642-39-4) + (2S,5R)-2-((S)-2-Benzenesulfonyl-1-phenyl-ethyl)-3,6-diethoxy-5-isopropyl-2,5-dihydro-pyrazine (170899-20-4)

Guidance literature:

In tetrahydrofuran; diethyl ether; at -70 ℃; for 0.25h;

DOI:10.1021/jo00121a010

Reference yield:

phenyl styryl sulfone (5418-11-1) + C11H19N2O2(1-)*Li(1+) → (2S,5R)-2-((R)-2-Benzenesulfonyl-1-phenyl-ethyl)-3,6-diethoxy-5-isopropyl-2,5-dihydro-pyrazine (170642-39-4) + (2S,5R)-2-((S)-2-Benzenesulfonyl-1-phenyl-ethyl)-3,6-diethoxy-5-isopropyl-2,5-dihydro-pyrazine (170899-20-4)

Guidance literature:

DOI:10.1021/jo00121a010

Reference yield:

(2S,5R)-2-((S)-2-Benzenesulfonyl-1-phenyl-ethyl)-3,6-diethoxy-5-isopropyl-2,5-dihydro-pyrazine (170899-20-4) → (2R,5S)-3,6-Diethoxy-2-isopropyl-5-((S)-1-phenyl-ethyl)-2,5-dihydro-pyrazine

Guidance literature:

With sodium amalgam;

DOI:10.1021/jo00121a010

upstream raw materials:

phenyl styryl sulfone

phenyl styryl sulfone