(1S,3R)-3-deoxy-1,25-dihydroxy-3-methylvitamin D₃

Base Information

Chemical Name:(1S,3R)-3-deoxy-1,25-dihydroxy-3-methylvitamin D₃
CAS No.:83076-48-6
Molecular Formula:C₂₈H₄₆O₂
Molecular Weight:414.672
Hs Code.:

(1S,3R)-3-deoxy-1,25-dihydroxy-3-methylvitamin D<sub>3</sub>

Synonyms:(1S,3R)-3-deoxy-1,25-dihydroxy-3-methylvitamin D₃

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (1S,3R)-3-deoxy-1,25-dihydroxy-3-methylvitamin D₃

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of (1S,3R)-3-deoxy-1,25-dihydroxy-3-methylvitamin D₃

There total 11 articles about (1S,3R)-3-deoxy-1,25-dihydroxy-3-methylvitamin D₃ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 61621-47-4
2,5-dimethyl-1,3-cyclohexanedione

: 83076-48-6
(1S,3R)-3-deoxy-1,25-dihydroxy-3-methylvitamin D₃

Guidance literature:: Multi-step reaction with 7 steps

1: 66 percent / iodine, triphenylphosphine, triethylamine / acetonitrile / 14 h / Heating

2: 67 percent / sodium borohydride / ethanol / 0.33 h

3: imidazole

4: 1.) tert-butyllithium, 2.) CuI, (n-Bu)3P, 3.) (n-Bu)4NF

5: 2,2,4-trimethyl-pentane / 11 h / 100 °C

6: 37 percent / triphenylphosphine, diethyl azodicarboxylate / benzene / 1 h

7: 1.) mercuric acetate, 2.) sodium borohydride, aq. NaOH, 3.) KOH, MeOH

With 1H-imidazole; methanol; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; copper(l) iodide; tributylphosphine; mercury(II) diacetate; tetrabutyl ammonium fluoride; iodine; tert.-butyl lithium; triethylamine; triphenylphosphine; diethylazodicarboxylate; In 2,2,4-trimethylpentane; ethanol; acetonitrile; benzene;
DOI:10.1021/ja00386a042

Reference yield:

: 66774-82-1
de-A,B-25-cholesten-8β-ol

: 83076-48-6
(1S,3R)-3-deoxy-1,25-dihydroxy-3-methylvitamin D₃

Guidance literature:: Multi-step reaction with 7 steps

1: 94 percent / pyridinium dichromate, pyridinium trifluoroacetate / CH₂Cl₂ / 4.5 h

2: 93 percent / n-butyllithium / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) room temperature, 1 h

3: 70 percent / n-butyllithium / tetrahydrofuran / 1.) -78 deg C, 2.) room temperature, 3 h

4: 1.) tert-butyllithium, 2.) CuI, (n-Bu)3P, 3.) (n-Bu)4NF

5: 2,2,4-trimethyl-pentane / 11 h / 100 °C

6: 37 percent / triphenylphosphine, diethyl azodicarboxylate / benzene / 1 h

7: 1.) mercuric acetate, 2.) sodium borohydride, aq. NaOH, 3.) KOH, MeOH

With methanol; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; copper(l) iodide; dipyridinium dichromate; n-butyllithium; tributylphosphine; mercury(II) diacetate; tetrabutyl ammonium fluoride; tert.-butyl lithium; pyridinium trifluroacetate; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 2,2,4-trimethylpentane; dichloromethane; benzene;
DOI:10.1021/ja00386a042

Reference yield:

: 83076-51-1
de-A,B-25-cholesten-8-one

: 83076-48-6
(1S,3R)-3-deoxy-1,25-dihydroxy-3-methylvitamin D₃

Guidance literature:: Multi-step reaction with 6 steps

1: 93 percent / n-butyllithium / tetrahydrofuran / 1.) -78 deg C, 1 h, 2.) room temperature, 1 h

2: 70 percent / n-butyllithium / tetrahydrofuran / 1.) -78 deg C, 2.) room temperature, 3 h

3: 1.) tert-butyllithium, 2.) CuI, (n-Bu)3P, 3.) (n-Bu)4NF

4: 2,2,4-trimethyl-pentane / 11 h / 100 °C

5: 37 percent / triphenylphosphine, diethyl azodicarboxylate / benzene / 1 h

6: 1.) mercuric acetate, 2.) sodium borohydride, aq. NaOH, 3.) KOH, MeOH

With methanol; potassium hydroxide; sodium hydroxide; sodium tetrahydroborate; copper(l) iodide; n-butyllithium; tributylphosphine; mercury(II) diacetate; tetrabutyl ammonium fluoride; tert.-butyl lithium; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 2,2,4-trimethylpentane; benzene;
DOI:10.1021/ja00386a042