C₂₁H₂₂N₂O₃S

Base Information

• Chemical Name: C₂₁H₂₂N₂O₃S
• CAS No.: 1221922-49-1
• Molecular Formula: C₂₁H₂₂N₂O₃S
• Molecular Weight: 382.483
• Mol file: 1221922-49-1.mol

Synonyms:C₂₁H₂₂N₂O₃S

Chemical Property of C₂₁H₂₂N₂O₃S

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₂₁H₂₂N₂O₃S

There total 4 articles about C₂₁H₂₂N₂O₃S which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

C15H10NO2S(1-)*Na(1+) (1221931-56-1) + glycine tert-butyl ester hydrochloride (27532-96-3) → C21H22N2O3S (1221922-49-1)

Guidance literature:

With pyridine; HATU; In N,N-dimethyl-formamide; at 20 ℃; for 4h; Inert atmosphere;

Reference yield:

6-bromo-2-chloro-benzothiazole (80945-86-4) → C21H22N2O3S (1221922-49-1)

Guidance literature:

Multi-step reaction with 4 steps

1.1: sodium hexamethyldisilazane / tetrahydrofuran; toluene / 1.17 h / -60 °C / Inert atmosphere

1.2: 2 h / 0 °C

2.1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 6 h / Reflux

3.1: water; sodium hydroxide / tetrahydrofuran / 0.67 h / 20 °C

4.1: pyridine; HATU / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

With pyridine; potassium phosphate; water; sodium hexamethyldisilazane; HATU; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide; toluene;

Reference yield:

ethyl 2-(6-bromobenzo[d]thiazol-2-yl)acetate (791614-78-3) → C21H22N2O3S (1221922-49-1)

Guidance literature:

Multi-step reaction with 3 steps

1: potassium phosphate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / 1,4-dioxane / 6 h / Reflux

2: water; sodium hydroxide / tetrahydrofuran / 0.67 h / 20 °C

3: pyridine; HATU / N,N-dimethyl-formamide / 4 h / 20 °C / Inert atmosphere

With pyridine; potassium phosphate; water; HATU; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; N,N-dimethyl-formamide;

upstream raw materials:

C₁₅H₁₀NO₂S^(1-)*Na⁽¹⁺⁾

glycine tert-butyl ester hydrochloride

ethyl 2-(6-bromobenzo[d]thiazol-2-yl)acetate

6-bromo-2-chloro-benzothiazole

Downstream raw materials:

C₁₇H₁₄N₂O₃S

C₁₉H₁₆N₄O₂S

Refernces