Technology Process of 3-(4-hydroxy-3,5-dimethylphenyl)-1-(3,5,5-trimethyl-4,5,6,7-tetrahydrobenzo[c]thiophen-1-yl)propenone
There total 9 articles about 3-(4-hydroxy-3,5-dimethylphenyl)-1-(3,5,5-trimethyl-4,5,6,7-tetrahydrobenzo[c]thiophen-1-yl)propenone which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogenchloride;
In
ethanol; isopropyl alcohol;
at 20 ℃;
for 1.66667h;
DOI:10.1021/jm401456d
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: hydrogen; palladium 10% on activated carbon / ethyl acetate / 2 h / 20 °C / 750.08 Torr
2.1: potassium tert-butylate / tetrahydrofuran; tert-butyl alcohol / 0.5 h / 20 °C / Cooling with ice
2.2: 0.83 h / 15 - 20 °C
3.1: oxalyl dichloride / chloroform / 1 h / 20 - 25 °C
4.1: sodium; ethanol / tetrahydrofuran / 1 h / 20 °C
5.1: sodium; ethanol / 0.25 h / 50 - 75 °C
6.1: water; lithium hydroxide / ethanol / 70 °C
7.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.25 h / -78 °C
7.2: 0.5 h / -78 °C
8.1: diethyl ether / 0.25 h / 20 - 26 °C
9.1: hydrogenchloride / ethanol; isopropyl alcohol / 1.67 h / 20 °C
With
hydrogenchloride; oxalyl dichloride; ethanol; palladium 10% on activated carbon; potassium tert-butylate; water; hydrogen; tert.-butyl lithium; sodium; lithium hydroxide;
In
tetrahydrofuran; diethyl ether; ethanol; chloroform; ethyl acetate; isopropyl alcohol; tert-butyl alcohol; pentane;
DOI:10.1021/jm401456d
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: sodium; ethanol / 0.25 h / 50 - 75 °C
2.1: water; lithium hydroxide / ethanol / 70 °C
3.1: tert.-butyl lithium / tetrahydrofuran; pentane / 0.25 h / -78 °C
3.2: 0.5 h / -78 °C
4.1: diethyl ether / 0.25 h / 20 - 26 °C
5.1: hydrogenchloride / ethanol; isopropyl alcohol / 1.67 h / 20 °C
With
hydrogenchloride; ethanol; water; tert.-butyl lithium; sodium; lithium hydroxide;
In
tetrahydrofuran; diethyl ether; ethanol; isopropyl alcohol; pentane;
DOI:10.1021/jm401456d
![1-(3,5,5-trimethyl-4,5,6,7-tetrahydrobenzo[c]thiophen-1-yl)ethanone](/Databaselist/images/loading.webp)
