N1-(5-monomethoxytrityloxyethoxyethyl)-5'-O-(para-toluenesulfonyl)-2',3'-O-isopropylideneinosine

Base Information

Chemical Name:N1-(5-monomethoxytrityloxyethoxyethyl)-5'-O-(para-toluenesulfonyl)-2',3'-O-isopropylideneinosine
CAS No.:1232139-71-7
Molecular Formula:C₄₄H₄₆N₄O₁₀S
Molecular Weight:822.936
Hs Code.:

Synonyms:N1-(5-monomethoxytrityloxyethoxyethyl)-5'-O-(para-toluenesulfonyl)-2',3'-O-isopropylideneinosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N1-(5-monomethoxytrityloxyethoxyethyl)-5'-O-(para-toluenesulfonyl)-2',3'-O-isopropylideneinosine

Chemical Property:

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Technology Process of N1-(5-monomethoxytrityloxyethoxyethyl)-5'-O-(para-toluenesulfonyl)-2',3'-O-isopropylideneinosine

There total 10 articles about N1-(5-monomethoxytrityloxyethoxyethyl)-5'-O-(para-toluenesulfonyl)-2',3'-O-isopropylideneinosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1232139-69-3
N1-(5-monomethoxytrityloxyethoxyethyl)-2',3'-O-isopropylideneinosine

: 98-59-9
p-toluenesulfonyl chloride

: 1232139-71-7
N1-(5-monomethoxytrityloxyethoxyethyl)-5'-O-(para-toluenesulfonyl)-2',3'-O-isopropylideneinosine

Guidance literature:: With dmap; triethylamine; In dichloromethane; at 20 ℃; for 8h;
DOI:10.1039/b9nj00595a

Reference yield:

: 1072463-01-4
C₂₅H₃₂N₆O₉Si

: 1232139-71-7
N1-(5-monomethoxytrityloxyethoxyethyl)-5'-O-(para-toluenesulfonyl)-2',3'-O-isopropylideneinosine

Guidance literature:: Multi-step reaction with 4 steps

1: N,N-dimethyl-formamide / 8 h / 50 °C

2: pyridine / 8 h / 20 °C

3: tetrabutyl ammonium fluoride; acetic acid / tetrahydrofuran / 2 h / 20 °C

4: dmap; triethylamine / dichloromethane / 8 h / 20 °C

With pyridine; dmap; tetrabutyl ammonium fluoride; acetic acid; triethylamine; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b9nj00595a

Reference yield:

: 924887-44-5
1-(2,4-dinitrophenyl)-2',3'-O-isopropylideneinosine

: 1232139-71-7
N1-(5-monomethoxytrityloxyethoxyethyl)-5'-O-(para-toluenesulfonyl)-2',3'-O-isopropylideneinosine

Guidance literature:: Multi-step reaction with 3 steps

1: dmap; triethylamine / dichloromethane / 8 h / 20 °C

2: N,N-dimethyl-formamide / 8 h / 50 °C

3: pyridine / 8 h / 20 °C

With pyridine; dmap; triethylamine; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1039/b9nj00595a