6,7-dimethoxy-2-methyl-1-phenyl-1,2,3,4-<1-D>tetrahydroisoquinoline

Base Information

• Chemical Name: 6,7-dimethoxy-2-methyl-1-phenyl-1,2,3,4-<1-D>tetrahydroisoquinoline
• CAS No.: 74688-58-7
• Molecular Formula: C₁₈H₂₁NO₂
• Molecular Weight: 284.362
• Mol file: 74688-58-7.mol

Synonyms:6,7-dimethoxy-2-methyl-1-phenyl-1,2,3,4-<1-D>tetrahydroisoquinoline

Chemical Property of 6,7-dimethoxy-2-methyl-1-phenyl-1,2,3,4-<1-D>tetrahydroisoquinoline

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6,7-dimethoxy-2-methyl-1-phenyl-1,2,3,4-<1-D>tetrahydroisoquinoline

There total 1 articles about 6,7-dimethoxy-2-methyl-1-phenyl-1,2,3,4-<1-D>tetrahydroisoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

6,7-dimethoxy-2-methyl-1-phenyl-3,4-dihydroisoquinolinium iodide (6075-62-3) → 6,7-dimethoxy-2-methyl-1-phenyl-1,2,3,4-<1-D>tetrahydroisoquinoline (74688-58-7)

Guidance literature:

With sodium borodeuteride; deuteromethanol; water-d2; at 20 ℃; for 12h;

DOI:10.1071/CH9800833

Reference yield: 59.0%

6,7-dimethoxy-2-methyl-1-phenyl-1,2,3,4-<1-D>tetrahydroisoquinoline (74688-58-7) → C18H20(2)HNO3 (74688-59-8)

Guidance literature:

With dihydrogen peroxide; at 20 ℃; for 40h;

DOI:10.1071/CH9800833

Reference yield:

6,7-dimethoxy-2-methyl-1-phenyl-1,2,3,4-<1-D>tetrahydroisoquinoline (74688-58-7) → 7,8-dimethoxy-3-methyl-1-phenyl-1,3,4,5-<1-D>tetrahydro-2,3-benzoxazepine

Guidance literature:

Multi-step reaction with 2 steps

1: 59 percent / 30percent aq. H₂O₂ / 40 h / 20 °C

2: 47 percent / 0.5 h / 120 °C

With dihydrogen peroxide;

DOI:10.1071/CH9800833

upstream raw materials:

6,7-dimethoxy-2-methyl-1-phenyl-3,4-dihydroisoquinolinium iodide

Downstream raw materials:

C₁₈H₂₀⁽²⁾HNO₃