Technology Process of (2R,3S,4aR,6S,8S,8aR)-2-Allyl-6-(3-benzyloxy-propyl)-2,8a-dimethyl-8-trimethylsilanyloxy-octahydro-pyrano[3,2-b]pyran-3-ol
There total 15 articles about (2R,3S,4aR,6S,8S,8aR)-2-Allyl-6-(3-benzyloxy-propyl)-2,8a-dimethyl-8-trimethylsilanyloxy-octahydro-pyrano[3,2-b]pyran-3-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium tetrahydroborate;
In
ethanol;
at -65 - 20 ℃;
for 2h;
DOI:10.1002/chem.200500993
- Guidance literature:
-
Multi-step reaction with 2 steps
1: 97 percent / NEt3 / dimethylformamide
2: 97 percent / NaBH4 / ethanol / 2 h / -65 - 20 °C
With
sodium tetrahydroborate; triethylamine;
In
ethanol; N,N-dimethyl-formamide;
DOI:10.1002/chem.200500993
- Guidance literature:
-
Multi-step reaction with 12 steps
1: 6.5 g / diethyl ether / 0.5 h / -65 - 20 °C
2: 85 percent / (i-Pr)2NEt
3: TiCl4; TMEDA; Zn / PbCl2 / CH2Cl2
4: PhCH=RuCH{[(Mes)NCH2CH2N(Mes)]}(PCy3)Cl2 / benzene / 20 °C
5: 92 percent / m-CPBA
6: 78 percent / NaH / tetrahydrofuran
7: PPTS; pyridine / toluene / 100 °C
8: 97 percent / DDQ; H2O / CH2Cl2
9: DEAD; PPh3 / toluene
10: NaOH / tetrahydrofuran; methanol
11: 97 percent / NEt3 / dimethylformamide
12: 97 percent / NaBH4 / ethanol / 2 h / -65 - 20 °C
With
pyridine; sodium hydroxide; sodium tetrahydroborate; N,N,N,N,-tetramethylethylenediamine; water; pyridinium p-toluenesulfonate; titanium tetrachloride; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; triphenylphosphine; 2,3-dicyano-5,6-dichloro-p-benzoquinone; zinc; diethylazodicarboxylate;
tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; lead(II) chloride;
In
tetrahydrofuran; methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide; toluene; benzene;
9: Mitsunobu inversion;
DOI:10.1002/chem.200500993
![(2R,4aR,6S,8S,8aR)-2-Allyl-6-(3-benzyloxy-propyl)-2,8a-dimethyl-8-trimethylsilanyloxy-hexahydro-pyrano[3,2-b]pyran-3-one](/Databaselist/images/loading.webp)
