{(1S,2S)-2-[(E)-2-(2,2-Dimethyl-[1,3]dioxan-5-yl)-vinyl]-1,3-dimethyl-4-triisopropylsilanyloxy-cyclohex-3-enyl}-methanol

Base Information

Chemical Name:{(1S,2S)-2-[(E)-2-(2,2-Dimethyl-[1,3]dioxan-5-yl)-vinyl]-1,3-dimethyl-4-triisopropylsilanyloxy-cyclohex-3-enyl}-methanol
CAS No.:155818-06-7
Molecular Formula:C₂₆H₄₈O₄Si
Molecular Weight:452.75
Hs Code.:

Synonyms:{(1S,2S)-2-[(E)-2-(2,2-Dimethyl-[1,3]dioxan-5-yl)-vinyl]-1,3-dimethyl-4-triisopropylsilanyloxy-cyclohex-3-enyl}-methanol

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Chemical Property of {(1S,2S)-2-[(E)-2-(2,2-Dimethyl-[1,3]dioxan-5-yl)-vinyl]-1,3-dimethyl-4-triisopropylsilanyloxy-cyclohex-3-enyl}-methanol

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Technology Process of {(1S,2S)-2-[(E)-2-(2,2-Dimethyl-[1,3]dioxan-5-yl)-vinyl]-1,3-dimethyl-4-triisopropylsilanyloxy-cyclohex-3-enyl}-methanol

There total 5 articles about {(1S,2S)-2-[(E)-2-(2,2-Dimethyl-[1,3]dioxan-5-yl)-vinyl]-1,3-dimethyl-4-triisopropylsilanyloxy-cyclohex-3-enyl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80522-42-5
triisopropylsilyl trifluoromethanesulfonate

: 155818-06-7
{(1S,2S)-2-[(E)-2-(2,2-Dimethyl-[1,3]dioxan-5-yl)-vinyl]-1,3-dimethyl-4-triisopropylsilanyloxy-cyclohex-3-enyl}-methanol

Guidance literature:: Multi-step reaction with 3 steps

1: 1.) LDA

2: 83 percent / oxazaborolidine derived from (R)-β-methyl-N-(p-tolylsulfonyl)tryptophan / CH2Cl2; toluene / 42 h / -78 °C

3: 99 percent / NaBH₄ / tetrahydrofuran; H₂O / 0.25 h / 0 °C

With sodium tetrahydroborate; oxazaborolidine derived from (R)-β-methyl-N-(p-tolylsulfonyl)tryptophan; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1021/ja00087a062

Reference yield:

: 102573-84-2
2,2-dimethyl-[1,3]dioxane-5-carbaldehyde

: 155818-06-7
{(1S,2S)-2-[(E)-2-(2,2-Dimethyl-[1,3]dioxan-5-yl)-vinyl]-1,3-dimethyl-4-triisopropylsilanyloxy-cyclohex-3-enyl}-methanol

Guidance literature:: Multi-step reaction with 4 steps

1: 2.) I₂

2: 1.) LDA

3: 83 percent / oxazaborolidine derived from (R)-β-methyl-N-(p-tolylsulfonyl)tryptophan / CH2Cl2; toluene / 42 h / -78 °C

4: 99 percent / NaBH₄ / tetrahydrofuran; H₂O / 0.25 h / 0 °C

With sodium tetrahydroborate; oxazaborolidine derived from (R)-β-methyl-N-(p-tolylsulfonyl)tryptophan; iodine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1021/ja00087a062

Reference yield:

: (E)-3-Methyl-5-(triphenyl-λ⁵-phosphanylidene)-pent-3-en-2-one

: 155818-06-7
{(1S,2S)-2-[(E)-2-(2,2-Dimethyl-[1,3]dioxan-5-yl)-vinyl]-1,3-dimethyl-4-triisopropylsilanyloxy-cyclohex-3-enyl}-methanol

Guidance literature:: Multi-step reaction with 4 steps

1: 2.) I₂

2: 1.) LDA

3: 83 percent / oxazaborolidine derived from (R)-β-methyl-N-(p-tolylsulfonyl)tryptophan / CH2Cl2; toluene / 42 h / -78 °C

4: 99 percent / NaBH₄ / tetrahydrofuran; H₂O / 0.25 h / 0 °C

With sodium tetrahydroborate; oxazaborolidine derived from (R)-β-methyl-N-(p-tolylsulfonyl)tryptophan; iodine; lithium diisopropyl amide; In tetrahydrofuran; dichloromethane; water; toluene;
DOI:10.1021/ja00087a062