2-chloro-4-[5-(1,1-dioxo-isothiazoiidin-2-ylmethyl)-pyridin-3-yl]-benzonitrile

Base Information

Chemical Name:2-chloro-4-[5-(1,1-dioxo-isothiazoiidin-2-ylmethyl)-pyridin-3-yl]-benzonitrile
CAS No.:1255870-19-9
Molecular Formula:C₁₆H₁₄ClN₃O₂S
Molecular Weight:347.825
Hs Code.:

Synonyms:2-chloro-4-[5-(1,1-dioxo-isothiazoiidin-2-ylmethyl)-pyridin-3-yl]-benzonitrile

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Chemical Property of 2-chloro-4-[5-(1,1-dioxo-isothiazoiidin-2-ylmethyl)-pyridin-3-yl]-benzonitrile

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Technology Process of 2-chloro-4-[5-(1,1-dioxo-isothiazoiidin-2-ylmethyl)-pyridin-3-yl]-benzonitrile

There total 3 articles about 2-chloro-4-[5-(1,1-dioxo-isothiazoiidin-2-ylmethyl)-pyridin-3-yl]-benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 548797-51-9
2-chloro-4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzonitrile

: 173999-31-0
2-(5-bromo-pyridin-3-ylmethyl)-isothiazolidine 1,1-dioxide

: 1255870-19-9
2-chloro-4-[5-(1,1-dioxo-isothiazoiidin-2-ylmethyl)-pyridin-3-yl]-benzonitrile

Guidance literature:: With sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; N,N-dimethyl-formamide; at 100 ℃; for 1h; Inert atmosphere;

Reference yield:

: 39741-46-3
3-bromo-5-(chloromethyl)-pyridine hydrochloride

: 1255870-19-9
2-chloro-4-[5-(1,1-dioxo-isothiazoiidin-2-ylmethyl)-pyridin-3-yl]-benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.33 h / 0 °C

1.2: 3 h / 20 °C

2.1: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 1 h / 100 °C / Inert atmosphere

With sodium hydride; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In water; N,N-dimethyl-formamide; mineral oil;

Reference yield:

: 154607-01-9
4-bromo-2-chlorobenzonitrile

: 1255870-19-9
2-chloro-4-[5-(1,1-dioxo-isothiazoiidin-2-ylmethyl)-pyridin-3-yl]-benzonitrile

Guidance literature:: Multi-step reaction with 2 steps

1: potassium acetate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / 1,4-dioxane / 4.5 h / 80 °C

2: sodium carbonate / dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂ / water; N,N-dimethyl-formamide / 1 h / 100 °C / Inert atmosphere

With potassium acetate; sodium carbonate; dichloro(1,1'-bis(diphenylphosphanyl)ferrocene)palladium(II)*CH₂Cl₂; In 1,4-dioxane; water; N,N-dimethyl-formamide;