2-(4-((6-(7-(2-fluoro-4-(phenoxycarbonylamino)phenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl acetate

Base Information

Chemical Name:2-(4-((6-(7-(2-fluoro-4-(phenoxycarbonylamino)phenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl acetate
CAS No.:1429308-00-8
Molecular Formula:C₃₄H₃₀FN₅O₆S
Molecular Weight:655.707
Hs Code.:

Synonyms:2-(4-((6-(7-(2-fluoro-4-(phenoxycarbonylamino)phenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl acetate

Suppliers and Price of 2-(4-((6-(7-(2-fluoro-4-(phenoxycarbonylamino)phenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl acetate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of 2-(4-((6-(7-(2-fluoro-4-(phenoxycarbonylamino)phenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl acetate

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of 2-(4-((6-(7-(2-fluoro-4-(phenoxycarbonylamino)phenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl acetate

There total 6 articles about 2-(4-((6-(7-(2-fluoro-4-(phenoxycarbonylamino)phenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl acetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1429308-01-9
C₃₀H₂₆FN₅O₃S

: 13831-31-7
Acetoxyacetyl chloride

: 1429308-00-8
2-(4-((6-(7-(2-fluoro-4-(phenoxycarbonylamino)phenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl acetate

Guidance literature:: With triethylamine; In dichloromethane; at 20 ℃; for 0.166667h;

Reference yield:

: 149806-06-4
6-bromonicotinaldehyde

: 1429308-00-8
2-(4-((6-(7-(2-fluoro-4-(phenoxycarbonylamino)phenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl acetate

Guidance literature:: Multi-step reaction with 6 steps

1.1: acetic acid; sodium tris(acetoxy)borohydride / dichloromethane / 16 h / 10 - 20 °C

2.1: n-butyllithium / tetrahydrofuran; hexane / 0.83 h / -40 - -27 °C

2.2: 0.33 h / -40 - -27 °C

2.3: 0.67 h / 20 °C / Reflux

3.1: potassium tert-butylate / dimethyl sulfoxide / 2 h / 80 °C

4.1: pyridine / 0.5 h

5.1: hydrogenchloride / methanol / 18 h / 20 °C

6.1: triethylamine / dichloromethane / 0.17 h / 20 °C

With pyridine; hydrogenchloride; n-butyllithium; potassium tert-butylate; sodium tris(acetoxy)borohydride; acetic acid; triethylamine; In tetrahydrofuran; methanol; hexane; dichloromethane; dimethyl sulfoxide;

Reference yield:

: 1429307-92-5
tert-butyl 4-((6-(7-chlorothieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazine-1-carboxylate

: 1429308-00-8
2-(4-((6-(7-(2-fluoro-4-(phenoxycarbonylamino)phenoxy)thieno[3,2-b]pyridin-2-yl)pyridin-3-yl)methyl)piperazin-1-yl)-2-oxoethyl acetate

Guidance literature:: Multi-step reaction with 4 steps

1: potassium tert-butylate / dimethyl sulfoxide / 2 h / 80 °C

2: pyridine / 0.5 h

3: hydrogenchloride / methanol / 18 h / 20 °C

4: triethylamine / dichloromethane / 0.17 h / 20 °C

With pyridine; hydrogenchloride; potassium tert-butylate; triethylamine; In methanol; dichloromethane; dimethyl sulfoxide;