[3-(3,4-Dichloro-benzyl)-6-methoxy-2-oxo-2,3-dihydro-indol-1-yl]-acetic acid

Base Information

Chemical Name:[3-(3,4-Dichloro-benzyl)-6-methoxy-2-oxo-2,3-dihydro-indol-1-yl]-acetic acid
CAS No.:114727-76-3
Molecular Formula:C₁₈H₁₅Cl₂NO₄
Molecular Weight:380.227
Hs Code.:

Synonyms:[3-(3,4-Dichloro-benzyl)-6-methoxy-2-oxo-2,3-dihydro-indol-1-yl]-acetic acid

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Chemical Property of [3-(3,4-Dichloro-benzyl)-6-methoxy-2-oxo-2,3-dihydro-indol-1-yl]-acetic acid

Chemical Property:

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Technology Process of [3-(3,4-Dichloro-benzyl)-6-methoxy-2-oxo-2,3-dihydro-indol-1-yl]-acetic acid

There total 4 articles about [3-(3,4-Dichloro-benzyl)-6-methoxy-2-oxo-2,3-dihydro-indol-1-yl]-acetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 114727-52-5
{3-[1-(3,4-Dichloro-phenyl)-meth-(E)-ylidene]-6-methoxy-2-oxo-2,3-dihydro-indol-1-yl}-acetic acid benzyl ester

: 114727-76-3
[3-(3,4-Dichloro-benzyl)-6-methoxy-2-oxo-2,3-dihydro-indol-1-yl]-acetic acid

Guidance literature:: With hydrogen; acetic acid; palladium on activated charcoal; In ethyl acetate; for 3h;
DOI:10.1016/0223-5234(92)90112-E

Reference yield:

: 7699-19-6
6-methoxyoxindole

: 114727-76-3
[3-(3,4-Dichloro-benzyl)-6-methoxy-2-oxo-2,3-dihydro-indol-1-yl]-acetic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 85 percent / pyrrolidine / methanol / 0.25 h / Heating

2: 1.) NaH / 1.) DMF, 25 deg C, 15 min, 2.) DMF, 30 min

3: H₂, AcOH / 5percent Pd/C / ethyl acetate / 3 h

With pyrrolidine; hydrogen; sodium hydride; acetic acid; palladium on activated charcoal; In methanol; ethyl acetate;
DOI:10.1016/0223-5234(92)90112-E

Reference yield:

: 114727-46-7
3-(3,4-dichlorobenzylidene)-6-methoxy-oxindole

: 114727-76-3
[3-(3,4-Dichloro-benzyl)-6-methoxy-2-oxo-2,3-dihydro-indol-1-yl]-acetic acid

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) NaH / 1.) DMF, 25 deg C, 15 min, 2.) DMF, 30 min

2: H₂, AcOH / 5percent Pd/C / ethyl acetate / 3 h

With hydrogen; sodium hydride; acetic acid; palladium on activated charcoal; In ethyl acetate;
DOI:10.1016/0223-5234(92)90112-E