C₂₇H₂₁F₅NOP

Base Information

• Chemical Name: C₂₇H₂₁F₅NOP
• CAS No.: 1590442-54-8
• Molecular Formula: C₂₇H₂₁F₅NOP
• Molecular Weight: 501.436
• Mol file: 1590442-54-8.mol

Synonyms:C₂₇H₂₁F₅NOP

Chemical Property of C₂₇H₂₁F₅NOP

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

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Technology Process of C₂₇H₂₁F₅NOP

There total 3 articles about C₂₇H₂₁F₅NOP which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 64.0%

C20H15F5NOP (1590442-19-5) + 4-methylphenylboronic acid (5720-05-8) → C27H21F5NOP (1590442-54-8)

Guidance literature:

With palladium diacetate; cesium fluoride; silver carbonate; p-benzoquinone; In N,N-dimethyl-formamide; at 40 ℃; for 12h; Inert atmosphere;

DOI:10.1002/chem.201303056

Reference yield:

di(o-tolyl)phosphinyl chloride (59472-84-3) → C27H21F5NOP (1590442-54-8)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; pyridine / 24 h / 110 °C

2: silver carbonate; cesium fluoride; palladium diacetate; p-benzoquinone / N,N-dimethyl-formamide / 12 h / 40 °C / Inert atmosphere

With pyridine; dmap; palladium diacetate; cesium fluoride; silver carbonate; p-benzoquinone; In N,N-dimethyl-formamide;

DOI:10.1002/chem.201303056

Reference yield:

2,3,4,5,6-pentafluoroaniline (771-60-8) → C27H21F5NOP (1590442-54-8)

Guidance literature:

Multi-step reaction with 2 steps

1: dmap; pyridine / 24 h / 110 °C

2: silver carbonate; cesium fluoride; palladium diacetate; p-benzoquinone / N,N-dimethyl-formamide / 12 h / 40 °C / Inert atmosphere

With pyridine; dmap; palladium diacetate; cesium fluoride; silver carbonate; p-benzoquinone; In N,N-dimethyl-formamide;

DOI:10.1002/chem.201303056

upstream raw materials:

C₂₀H₁₅F₅NOP

4-methylphenylboronic acid

di(o-tolyl)phosphinyl chloride

2,3,4,5,6-pentafluoroaniline