2-{2-[(1R,2R)-1-(2-chlorobenzyl)-2-ethoxycarbonyl-2-hydroxyethylcarbamoyl]pyridin-4-yl}benzoic acid ethyl ester trifluoroacetic acid salt

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Chemical Name:2-{2-[(1R,2R)-1-(2-chlorobenzyl)-2-ethoxycarbonyl-2-hydroxyethylcarbamoyl]pyridin-4-yl}benzoic acid ethyl ester trifluoroacetic acid salt
CAS No.:1415310-29-0
Molecular Formula:C₂HF₃O₂*C₂₇H₂₇ClN₂O₆
Molecular Weight:624.998
Hs Code.:

Synonyms:2-{2-[(1R,2R)-1-(2-chlorobenzyl)-2-ethoxycarbonyl-2-hydroxyethylcarbamoyl]pyridin-4-yl}benzoic acid ethyl ester trifluoroacetic acid salt

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Chemical Property of 2-{2-[(1R,2R)-1-(2-chlorobenzyl)-2-ethoxycarbonyl-2-hydroxyethylcarbamoyl]pyridin-4-yl}benzoic acid ethyl ester trifluoroacetic acid salt

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Technology Process of 2-{2-[(1R,2R)-1-(2-chlorobenzyl)-2-ethoxycarbonyl-2-hydroxyethylcarbamoyl]pyridin-4-yl}benzoic acid ethyl ester trifluoroacetic acid salt

There total 8 articles about 2-{2-[(1R,2R)-1-(2-chlorobenzyl)-2-ethoxycarbonyl-2-hydroxyethylcarbamoyl]pyridin-4-yl}benzoic acid ethyl ester trifluoroacetic acid salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1415312-56-9
(2R,3R)-3-[(4-bromo-pyridine-2-carbonyl)-amino]-4-(2-chloro-phenyl)-2-hydroxy-butyric acid ethyl ester

: 76-05-1
trifluoroacetic acid

: 269409-99-6
ethyl 2-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)benzoate

: 1415310-29-0
2-{2-[(1R,2R)-1-(2-chlorobenzyl)-2-ethoxycarbonyl-2-hydroxyethylcarbamoyl]pyridin-4-yl}benzoic acid ethyl ester trifluoroacetic acid salt

Guidance literature:: (2R,3R)-3-[(4-bromo-pyridine-2-carbonyl)-amino]-4-(2-chloro-phenyl)-2-hydroxy-butyric acid ethyl ester; ethyl 2-(4,4,5,5-tetramethyl[1,3,2]dioxaborolan-2-yl)benzoate; With potassium carbonate; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; water; toluene; at 100 ℃; for 0.5h; Inert atmosphere;

trifluoroacetic acid; In water; acetonitrile;

Reference yield:

: 80126-50-7
(R)-2'-chlorophenylalanine

: 1415310-29-0
2-{2-[(1R,2R)-1-(2-chlorobenzyl)-2-ethoxycarbonyl-2-hydroxyethylcarbamoyl]pyridin-4-yl}benzoic acid ethyl ester trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 8 steps

1.1: sodium hydroxide / water; acetone / 4 h / 0 °C / pH 8 - 9

2.1: triethylamine; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide / dichloromethane / 20 °C / Inert atmosphere

3.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / -20 °C / Inert atmosphere

4.1: sodium hydrogensulfite / water; tetrahydrofuran / 0 °C / Inert atmosphere

4.2: 3 h / Inert atmosphere

5.1: hydrogenchloride; water / 1,4-dioxane / Inert atmosphere; Reflux

6.1: hydrogenchloride / 4 h / Reflux; Inert atmosphere

7.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0.75 h / 20 °C / Industry scale

8.1: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 0.5 h / 100 °C / Inert atmosphere

With hydrogenchloride; lithium aluminium tetrahydride; water; potassium carbonate; benzotriazol-1-ol; sodium hydrogensulfite; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; N-ethyl-N,N-diisopropylamine; HATU; sodium hydroxide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; water; acetone; toluene;

Reference yield:

: 1415312-30-9
(2R,3R)-3-Amino-4-(2-chloro-phenyl)-2-hydroxy-butyric acid ethyl ester

: 1415310-29-0
2-{2-[(1R,2R)-1-(2-chlorobenzyl)-2-ethoxycarbonyl-2-hydroxyethylcarbamoyl]pyridin-4-yl}benzoic acid ethyl ester trifluoroacetic acid salt

Guidance literature:: Multi-step reaction with 2 steps

1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0.75 h / 20 °C / Industry scale

2: potassium carbonate / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / toluene; ethanol; water / 0.5 h / 100 °C / Inert atmosphere

With potassium carbonate; N-ethyl-N,N-diisopropylamine; HATU; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In ethanol; dichloromethane; water; toluene;