N-acetyl-cyclo-(L-lysyl-L-glutamyl)-cyclo(D-lysyl-D-glutamyl) N'-methylamide

Base Information

Chemical Name:N-acetyl-cyclo-(L-lysyl-L-glutamyl)-cyclo(D-lysyl-D-glutamyl) N'-methylamide
CAS No.:110473-39-7
Molecular Formula:C₂₅H₄₁N₇O₇
Molecular Weight:551.643
Hs Code.:

Synonyms:N-acetyl-cyclo-(L-lysyl-L-glutamyl)-cyclo(D-lysyl-D-glutamyl) N'-methylamide

Suppliers and Price of N-acetyl-cyclo-(L-lysyl-L-glutamyl)-cyclo(D-lysyl-D-glutamyl) N'-methylamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-acetyl-cyclo-(L-lysyl-L-glutamyl)-cyclo(D-lysyl-D-glutamyl) N'-methylamide

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Technology Process of N-acetyl-cyclo-(L-lysyl-L-glutamyl)-cyclo(D-lysyl-D-glutamyl) N'-methylamide

There total 1 articles about N-acetyl-cyclo-(L-lysyl-L-glutamyl)-cyclo(D-lysyl-D-glutamyl) N'-methylamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 35793-73-8
N-(tert-butyloxycarbonyl)-γ-benzyl-D-glutamic acid

: 110473-39-7
N-acetyl-cyclo-(L-lysyl-L-glutamyl)-cyclo(D-lysyl-D-glutamyl) N'-methylamide

Guidance literature:: Multi-step reaction with 10 steps

1: 89 percent / ethanol; diethyl ether / 1 h / 0 °C

2: H₂ / 10percent Pd/C / methanol / 4 h / 760 Torr

3: 84 percent / N,N'-dicyclohexylcarbodiimide (DCC) / tetrahydrofuran; CH₂Cl₂ / 18 h

4: aq. sodium bicarbonate / tetrahydrofuran / 11 h

5: 86 percent / N,N'-dicyclohexylcarbodiimide (DCC) / tetrahydrofuran; CH₂Cl₂ / 19 h

6: 100 percent / 4 N HCl / dioxane / 4 h

7: 46 percent / pyridine / dimethylformamide / 12 h / 60 °C

8: 95 percent / methanol / 1.) 0 deg C, 30 min, 2.) RT, 12 h

9: H₂ / 10percent Pd/C / methanol / 12 h / 760 Torr

10: triethylamine / dimethylformamide; dioxane / 1.) -20 deg C, 1 h, 2.) 0 deg C, 24 h

With pyridine; hydrogenchloride; hydrogen; sodium hydrogencarbonate; triethylamine; dicyclohexyl-carbodiimide; palladium on activated charcoal; In tetrahydrofuran; 1,4-dioxane; methanol; diethyl ether; ethanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jo00233a006