5'-O-(monomethoxytrityl)-2'-O-(tert-butyldiphenylsilyl)-3'-O-trifluoromethanesulfonyladenosine

Base Information

Chemical Name:5'-O-(monomethoxytrityl)-2'-O-(tert-butyldiphenylsilyl)-3'-O-trifluoromethanesulfonyladenosine
CAS No.:131372-48-0
Molecular Formula:C₄₇H₄₆F₃N₅O₇SSi
Molecular Weight:910.058
Hs Code.:

Synonyms:5'-O-(monomethoxytrityl)-2'-O-(tert-butyldiphenylsilyl)-3'-O-trifluoromethanesulfonyladenosine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 5'-O-(monomethoxytrityl)-2'-O-(tert-butyldiphenylsilyl)-3'-O-trifluoromethanesulfonyladenosine

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Technology Process of 5'-O-(monomethoxytrityl)-2'-O-(tert-butyldiphenylsilyl)-3'-O-trifluoromethanesulfonyladenosine

There total 3 articles about 5'-O-(monomethoxytrityl)-2'-O-(tert-butyldiphenylsilyl)-3'-O-trifluoromethanesulfonyladenosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 358-23-6
trifluoromethylsulfonic anhydride

: 131372-46-8
5'-O-(monomethoxytrityl)-2'-O-(tert-butyldiphenylsilyl)adenosine

: 131372-48-0
5'-O-(monomethoxytrityl)-2'-O-(tert-butyldiphenylsilyl)-3'-O-trifluoromethanesulfonyladenosine

Guidance literature:: With dmap; triethylamine; In dichloromethane; 1) -20 deg C, 1 h, 2) rt, 6 h;
DOI:10.1055/s-1990-27048

Reference yield:

: 51600-11-4
5'-O-(p-methoxyphenyldiphenylmethyl)adenosine

: 131372-48-0
5'-O-(monomethoxytrityl)-2'-O-(tert-butyldiphenylsilyl)-3'-O-trifluoromethanesulfonyladenosine

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / pyridine, AgNO₃ / tetrahydrofuran / 48 h / Ambient temperature

2: 78 percent / DMAP, Et₃N / CH₂Cl₂ / 1) -20 deg C, 1 h, 2) rt, 6 h

With pyridine; dmap; silver nitrate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-1990-27048

Reference yield:

: 58479-61-1
tert-butylchlorodiphenylsilane

: 131372-48-0
5'-O-(monomethoxytrityl)-2'-O-(tert-butyldiphenylsilyl)-3'-O-trifluoromethanesulfonyladenosine

Guidance literature:: Multi-step reaction with 2 steps

1: 64 percent / pyridine, AgNO₃ / tetrahydrofuran / 48 h / Ambient temperature

2: 78 percent / DMAP, Et₃N / CH₂Cl₂ / 1) -20 deg C, 1 h, 2) rt, 6 h

With pyridine; dmap; silver nitrate; triethylamine; In tetrahydrofuran; dichloromethane;
DOI:10.1055/s-1990-27048