(S)-4-bromobenzyl 2-(((S)-3-(benzyloxy)-1-cyano-3-oxopropyl)carbamoyl)pyrrolidine-1-carboxylate

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Chemical Name:(S)-4-bromobenzyl 2-(((S)-3-(benzyloxy)-1-cyano-3-oxopropyl)carbamoyl)pyrrolidine-1-carboxylate
CAS No.:1609689-75-9
Molecular Formula:C₂₄H₂₄BrN₃O₅
Molecular Weight:514.376
Hs Code.:

Synonyms:(S)-4-bromobenzyl 2-(((S)-3-(benzyloxy)-1-cyano-3-oxopropyl)carbamoyl)pyrrolidine-1-carboxylate

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Chemical Property of (S)-4-bromobenzyl 2-(((S)-3-(benzyloxy)-1-cyano-3-oxopropyl)carbamoyl)pyrrolidine-1-carboxylate

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Technology Process of (S)-4-bromobenzyl 2-(((S)-3-(benzyloxy)-1-cyano-3-oxopropyl)carbamoyl)pyrrolidine-1-carboxylate

There total 5 articles about (S)-4-bromobenzyl 2-(((S)-3-(benzyloxy)-1-cyano-3-oxopropyl)carbamoyl)pyrrolidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.0%

: 1618080-03-7
C₂₄H₂₆BrN₃O₆

: 1609689-75-9
(S)-4-bromobenzyl 2-(((S)-3-(benzyloxy)-1-cyano-3-oxopropyl)carbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: C₂₄H₂₆BrN₃O₆; With 1,3,5-trichloro-2,4,6-triazine; In N,N-dimethyl-formamide; at 20 ℃; for 3h; Inert atmosphere;

Inert atmosphere;
DOI:10.1016/j.bmcl.2014.04.002

Reference yield:

: 144332-74-1
(S)-1-(4-bromobenzyl)2-methyl pyrrolidine-1,2-dicarboxylate

: 1609689-75-9
(S)-4-bromobenzyl 2-(((S)-3-(benzyloxy)-1-cyano-3-oxopropyl)carbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 3 steps

1.1: lithium hydroxide; water / methanol; tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

2.1: 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

3.1: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

3.2: Inert atmosphere

With 4-methyl-morpholine; 1,3,5-trichloro-2,4,6-triazine; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide;
DOI:10.1016/j.bmcl.2014.04.002

Reference yield:

: 38065-38-2
(4-bromophenyl)methyl 4-nitrophenyl carbonate

: 1609689-75-9
(S)-4-bromobenzyl 2-(((S)-3-(benzyloxy)-1-cyano-3-oxopropyl)carbamoyl)pyrrolidine-1-carboxylate

Guidance literature:: Multi-step reaction with 4 steps

1.1: 4-methyl-morpholine / tetrahydrofuran; acetonitrile / 3 h / Reflux; Inert atmosphere

2.1: lithium hydroxide; water / methanol; tetrahydrofuran / 3 h / 20 °C / Inert atmosphere

3.1: 4-methyl-morpholine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 24 h / 20 °C / Inert atmosphere

4.1: 1,3,5-trichloro-2,4,6-triazine / N,N-dimethyl-formamide / 3 h / 20 °C / Inert atmosphere

4.2: Inert atmosphere

With 4-methyl-morpholine; 1,3,5-trichloro-2,4,6-triazine; water; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; lithium hydroxide; In tetrahydrofuran; methanol; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.bmcl.2014.04.002