methyl 4,7-dihydro-3-isobutyl-7-methoxymethyl-6-methyl-4-(3-nitrophenyl)thieno<2,3-b>pyridine-5-carboxylate

Base Information

• Chemical Name: methyl 4,7-dihydro-3-isobutyl-7-methoxymethyl-6-methyl-4-(3-nitrophenyl)thieno<2,3-b>pyridine-5-carboxylate
• CAS No.: 120057-28-5
• Molecular Formula: C₂₂H₂₆N₂O₅S
• Molecular Weight: 430.525

Synonyms:methyl 4,7-dihydro-3-isobutyl-7-methoxymethyl-6-methyl-4-(3-nitrophenyl)thieno<2,3-b>pyridine-5-carboxylate

Chemical Property of methyl 4,7-dihydro-3-isobutyl-7-methoxymethyl-6-methyl-4-(3-nitrophenyl)thieno<2,3-b>pyridine-5-carboxylate

Chemical Property:

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Technology Process of methyl 4,7-dihydro-3-isobutyl-7-methoxymethyl-6-methyl-4-(3-nitrophenyl)thieno<2,3-b>pyridine-5-carboxylate

There total 22 articles about methyl 4,7-dihydro-3-isobutyl-7-methoxymethyl-6-methyl-4-(3-nitrophenyl)thieno<2,3-b>pyridine-5-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 99.7%

diazomethane (186581-53-3,908094-01-9,334-88-3) + (+)-4,7-dihydro-3-isobutyl-7-methoxymethyl-6-methyl-4-(3-nitrophenyl)thieno<2,3-b>pyridine-5-carboxylic acid (120004-31-1,120056-59-9,120056-60-2) → 3-Isobutyl-7-methoxymethyl-6-methyl-4-(3-nitro-phenyl)-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid methyl ester (120004-32-2,120027-28-3,120057-28-5)

Guidance literature:

In diethyl ether; for 0.5h; Ambient temperature;

DOI:10.1248/cpb.36.4389

Reference yield: 97.6%

diazomethane (186581-53-3,908094-01-9,334-88-3) + (-)-4,7-dihydro-3-isobutyl-7-methoxymethyl-6-methyl-4-(3-nitrophenyl)thieno<2,3-b>pyridine-5-carboxylic acid (120004-31-1,120056-59-9,120056-60-2) → 3-Isobutyl-7-methoxymethyl-6-methyl-4-(3-nitro-phenyl)-4,7-dihydro-thieno[2,3-b]pyridine-5-carboxylic acid methyl ester (120004-32-2,120027-28-3,120057-28-5)

Guidance literature:

In diethyl ether; Ambient temperature;

DOI:10.1248/cpb.36.4389

Reference yield: 80.5%

chloromethyl methyl ether (107-30-2) + S-312 (120004-07-1) → methyl 4,7-dihydro-3-isobutyl-7-methoxymethyl-6-methyl-4-(3-nitrophenyl)thieno<2,3-b>pyridine-5-carboxylate (120057-28-5)

Guidance literature:

With sodium hydroxide; oil; In tetrahydrofuran; at 3 - 8 ℃; for 1h;

DOI:10.1248/cpb.36.4389

upstream raw materials:

chloromethyl methyl ether

S-312

tert-butyl 5-methyl-3-oxohexanoate

methyl 2-E,Z-(3-nitro-phenylmethylen)-3-oxobutanoate

Downstream raw materials:

(+)-4,7-dihydro-3-isobutyl-7-methoxymethyl-6-methyl-4-(3-nitrophenyl)thieno<2,3-b>pyridine-5-carboxylic acid

(-)-4,7-dihydro-3-isobutyl-7-methoxymethyl-6-methyl-4-(3-nitrophenyl)thieno<2,3-b>pyridine-5-carboxylic acid

R-(-)-methyl 2-bromo-4,7-dihydro-3-isobutyl-7-methoxymethyl-6-methyl-4-(3-nitrophenyl)thieno<2,3-b>pyridine-5-carboxylate

(+)-methyl 4,7-dihydro-3-isobutyl-6-methyl-4-(3-nitrophenyl)thieno<2,3-b>pyridine-5-carboxylate

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