Technology Process of decahydro-3-benzyl-3aβ,5aβ,9aβ,9bβ-2H-thieno<3,4,5-de>cyclohepta<1,3>oxazin-2-one
There total 8 articles about decahydro-3-benzyl-3aβ,5aβ,9aβ,9bβ-2H-thieno<3,4,5-de>cyclohepta<1,3>oxazin-2-one which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydroxide;
In
methanol;
for 18h;
Heating;
DOI:10.1021/ja00526a033
- Guidance literature:
-
Multi-step reaction with 7 steps
1: 71 percent / triethylamine / acetonitrile / 2 h / 25 °C / edducts were added at 0 deg C
2: 1.) sodium ethoxide / 1.) ethanol, reflux, 0.25 h, 2.) 2 h
3: 100 percent / p-toluenesulfonic acid hydrate / acetone; H2O / 1 h / Heating
4: 66 percent / triethylamine / acetonitrile / 2 h / Heating
5: 96 percent / zinc, acetic acid / H2O / 18 h / 70 °C
6: 100 percent / NaHCO3 / methanol / 3 h
7: 100 percent / sodium hydroxide / methanol / 18 h / Heating
With
sodium hydroxide; sodium ethanolate; sodium hydrogencarbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; zinc;
In
methanol; water; acetone; acetonitrile;
DOI:10.1021/ja00526a033
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 1.) sodium ethoxide / 1.) ethanol, reflux, 0.25 h, 2.) 2 h
2: 100 percent / p-toluenesulfonic acid hydrate / acetone; H2O / 1 h / Heating
3: 66 percent / triethylamine / acetonitrile / 2 h / Heating
4: 96 percent / zinc, acetic acid / H2O / 18 h / 70 °C
5: 100 percent / NaHCO3 / methanol / 3 h
6: 100 percent / sodium hydroxide / methanol / 18 h / Heating
With
sodium hydroxide; sodium ethanolate; sodium hydrogencarbonate; toluene-4-sulfonic acid; acetic acid; triethylamine; zinc;
In
methanol; water; acetone; acetonitrile;
DOI:10.1021/ja00526a033
