(R)-N-Boc-2-(3,4-dimethoxy)phenylpiperidine

Base Information

Chemical Name:(R)-N-Boc-2-(3,4-dimethoxy)phenylpiperidine
CAS No.:1261081-79-1
Molecular Formula:C₁₈H₂₇NO₄
Molecular Weight:321.417
Hs Code.:

Synonyms:(R)-N-Boc-2-(3,4-dimethoxy)phenylpiperidine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (R)-N-Boc-2-(3,4-dimethoxy)phenylpiperidine

Chemical Property:

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Technology Process of (R)-N-Boc-2-(3,4-dimethoxy)phenylpiperidine

There total 4 articles about (R)-N-Boc-2-(3,4-dimethoxy)phenylpiperidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 2859-78-1
4-Bromoveratrole

: 75844-69-8
t-butyl piperidinecarboxylate

: 1261081-79-1
(R)-N-Boc-2-(3,4-dimethoxy)phenylpiperidine

Guidance literature:: t-butyl piperidinecarboxylate; With N,N,N,N,-tetramethylethylenediamine; sec.-butyllithium; In diethyl ether; cyclohexane; at -78 ℃; for 3h; Inert atmosphere;

With C₁₂H₂₄N₂O^(2-)*2Li⁽¹⁺⁾; In diethyl ether; cyclohexane; at -78 - -45 ℃; for 5h; Inert atmosphere;

4-Bromoveratrole; optical yield given as %ee; enantioselective reaction; Further stages;
DOI:10.1021/ol102682r

Reference yield:

: 2859-78-1
4-Bromoveratrole

: C₁₀H₁₈LiNO₂*C₆H₁₆N₂

: 1261081-79-1
(R)-N-Boc-2-(3,4-dimethoxy)phenylpiperidine

Guidance literature:: C₁₀H₁₈LiNO₂*C₆H₁₆N₂; With C₁₂H₂₄N₂O^(2-)*2Li⁽¹⁺⁾; In diethyl ether; at -45 ℃; for 5h; Inert atmosphere;

With zinc(II) chloride; In diethyl ether; at -80 - 20 ℃; for 0.5h; Inert atmosphere;

4-Bromoveratrole; With palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate; In diethyl ether; at 20 ℃; for 18h; enantioselective reaction; Inert atmosphere;
DOI:10.1021/ja306276w

Reference yield:

: 2859-78-1
4-Bromoveratrole

: 75844-69-8
t-butyl piperidinecarboxylate

: 1228307-53-6
tert-butyl (S)-2-(3,4-dimethoxyphenyl)piperidine-1-carboxylate

: 1261081-79-1
(R)-N-Boc-2-(3,4-dimethoxy)phenylpiperidine

Guidance literature:: t-butyl piperidinecarboxylate; With sec.-butyllithium; (1R,5S,11aS)-3-methyldecahydro-1H-1,5-methanopyrido[1,2-a][1,5]diazocine; In hexanes; diethyl ether; at -78 ℃; for 6h; Inert atmosphere;

With zinc(II) chloride; In hexanes; diethyl ether; at -78 - 20 ℃; for 1.08333h;

4-Bromoveratrole; With palladium diacetate; tri tert-butylphosphoniumtetrafluoroborate; In hexanes; diethyl ether; at 20 ℃; for 16h; optical yield given as %ee;
DOI:10.1021/ja102043e