(S)-3-[(S)-3-((R)-3-{(S)-3-[(S)-3-((R)-3-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-butyrylamino]-5-methyl-hexanoylamino}-4-methyl-pentanoylamino)-butyrylamino]-5-methyl-hexanoic acid pentafluorophenyl ester

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Chemical Name:(S)-3-[(S)-3-((R)-3-{(S)-3-[(S)-3-((R)-3-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-butyrylamino]-5-methyl-hexanoylamino}-4-methyl-pentanoylamino)-butyrylamino]-5-methyl-hexanoic acid pentafluorophenyl ester
CAS No.:181075-77-4
Molecular Formula:C₄₅H₇₁F₅N₆O₉
Molecular Weight:935.086
Hs Code.:

(S)-3-[(S)-3-((R)-3-{(S)-3-[(S)-3-((R)-3-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-butyrylamino]-5-methyl-hexanoylamino}-4-methyl-pentanoylamino)-butyrylamino]-5-methyl-hexanoic acid pentafluorophenyl ester

Synonyms:(S)-3-[(S)-3-((R)-3-{(S)-3-[(S)-3-((R)-3-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-butyrylamino]-5-methyl-hexanoylamino}-4-methyl-pentanoylamino)-butyrylamino]-5-methyl-hexanoic acid pentafluorophenyl ester

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Chemical Property of (S)-3-[(S)-3-((R)-3-{(S)-3-[(S)-3-((R)-3-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-butyrylamino]-5-methyl-hexanoylamino}-4-methyl-pentanoylamino)-butyrylamino]-5-methyl-hexanoic acid pentafluorophenyl ester

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Technology Process of (S)-3-[(S)-3-((R)-3-{(S)-3-[(S)-3-((R)-3-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-butyrylamino]-5-methyl-hexanoylamino}-4-methyl-pentanoylamino)-butyrylamino]-5-methyl-hexanoic acid pentafluorophenyl ester

There total 16 articles about (S)-3-[(S)-3-((R)-3-{(S)-3-[(S)-3-((R)-3-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-butyrylamino]-5-methyl-hexanoylamino}-4-methyl-pentanoylamino)-butyrylamino]-5-methyl-hexanoic acid pentafluorophenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 80.0%

: 771-61-9
2,3,4,5,6-pentafluorophenol

: 181075-75-2
Boc-(R)-β³-hVal-(S)-β³-hAla-(S)-β³-hLeu-(R)-β³-hVal-(S)-β³-hAla-(S)-β³-hLeu-OH

: 181075-77-4
(S)-3-[(S)-3-((R)-3-{(S)-3-[(S)-3-((R)-3-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-butyrylamino]-5-methyl-hexanoylamino}-4-methyl-pentanoylamino)-butyrylamino]-5-methyl-hexanoic acid pentafluorophenyl ester

Guidance literature:: With N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; In N,N-dimethyl-formamide; for 16h; Ambient temperature;
DOI:10.1002/hlca.19960790402

Reference yield:

: 13734-41-3
t-Boc-L-valine

: 181075-77-4
(S)-3-[(S)-3-((R)-3-{(S)-3-[(S)-3-((R)-3-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-butyrylamino]-5-methyl-hexanoylamino}-4-methyl-pentanoylamino)-butyrylamino]-5-methyl-hexanoic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 7 steps

1: Et₃N / -15 °C

2: -5 deg C to room t.

3: 1.) Et3N / 1.) MeCN, room t., 2.) MeCN, hν, 16 h

4: 97 percent / 0.75 N NaOH / methanol / 4 h / Ambient temperature

5: 1.) Et₃N, 2.) HOBt, EDC / 1.) CHCl₃, 0 deg C, 2.) CHCl₃, DMF, 0 deg C to room t., 16 h

6: 1.) 5 N NaOH, 2.) Dowex-H⁺ 50x8 / 1.) CF₃CH₂OH, 50 deg C, 24 h

7: 80 percent / EDC / dimethylformamide / 16 h / Ambient temperature

With sodium hydroxide; Dowex-H⁺ 50x8; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19960790402

Reference yield:

: 98807-40-0
Boc-Val-O-COOEt

: 181075-77-4
(S)-3-[(S)-3-((R)-3-{(S)-3-[(S)-3-((R)-3-tert-Butoxycarbonylamino-4-methyl-pentanoylamino)-butyrylamino]-5-methyl-hexanoylamino}-4-methyl-pentanoylamino)-butyrylamino]-5-methyl-hexanoic acid pentafluorophenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: -5 deg C to room t.

2: 1.) Et3N / 1.) MeCN, room t., 2.) MeCN, hν, 16 h

3: 97 percent / 0.75 N NaOH / methanol / 4 h / Ambient temperature

4: 1.) Et₃N, 2.) HOBt, EDC / 1.) CHCl₃, 0 deg C, 2.) CHCl₃, DMF, 0 deg C to room t., 16 h

5: 1.) 5 N NaOH, 2.) Dowex-H⁺ 50x8 / 1.) CF₃CH₂OH, 50 deg C, 24 h

6: 80 percent / EDC / dimethylformamide / 16 h / Ambient temperature

With sodium hydroxide; Dowex-H⁺ 50x8; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In methanol; N,N-dimethyl-formamide;
DOI:10.1002/hlca.19960790402