(E)-(2R,5S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-3,4-dimethyl-8-trityloxy-oct-3-en-2-ol

Base Information

Chemical Name:(E)-(2R,5S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-3,4-dimethyl-8-trityloxy-oct-3-en-2-ol
CAS No.:191034-60-3
Molecular Formula:C₃₆H₅₀O₃Si
Molecular Weight:558.877
Hs Code.:

Synonyms:(E)-(2R,5S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-3,4-dimethyl-8-trityloxy-oct-3-en-2-ol

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Chemical Property of (E)-(2R,5S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-3,4-dimethyl-8-trityloxy-oct-3-en-2-ol

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Technology Process of (E)-(2R,5S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-3,4-dimethyl-8-trityloxy-oct-3-en-2-ol

There total 1 articles about (E)-(2R,5S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-3,4-dimethyl-8-trityloxy-oct-3-en-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (E)-(2S,5R)-5-Benzyloxymethoxy-2-(3-benzyloxy-propyl)-3,4-dimethyl-hex-3-en-1-ol

: 191034-60-3
(E)-(2R,5S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-3,4-dimethyl-8-trityloxy-oct-3-en-2-ol

Guidance literature:: Multistep reaction;
DOI:10.1016/0040-4039(94)88416-1

Reference yield: 98.0%

: 18871-66-4
N,N-dimethylacetamide dimethyl acetal

: 191034-60-3
(E)-(2R,5S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-3,4-dimethyl-8-trityloxy-oct-3-en-2-ol

: 191034-64-7
(3S,3(1S),4E)-3-<1-(((tert-bytyldimethylsilyl)oxy)methyl)-4-(trityloxy)butyl>-3,4-dimethylhex-4-enoic acid dimethyl amide

Guidance literature:: In toluene; at 110 ℃; for 4h;
DOI:10.1021/ja9700515

Reference yield:

: 191034-60-3
(E)-(2R,5S)-5-(tert-Butyl-dimethyl-silanyloxymethyl)-3,4-dimethyl-8-trityloxy-oct-3-en-2-ol

: 191034-80-7
(3S,4S)-4-{[(tert-bytyldimethylsilyl)oxy]methyl}-3-methyl-7-(trityloxy)-3-[2-(trityloxy)ethyl]heptan-2-one

Guidance literature:: Multi-step reaction with 5 steps

1: 98 percent / toluene / 4 h / 110 °C

2: Na₂HPO₄, m-CPBA / CH₂Cl₂ / 4 h

3: 73 percent / LAH

4: DMAP / pyridine / 48 h / Ambient temperature

5: Pb(OAc)4 / CH₂Cl₂ / 0.08 h

With lead(IV) acetate; dmap; disodium hydrogenphosphate; lithium aluminium tetrahydride; 3-chloro-benzenecarboperoxoic acid; In pyridine; dichloromethane; toluene;
DOI:10.1021/ja9700515