6,6'-dimethyl-4,4'-bis(3-bromo-4-hydroxy-5-tert-butylbenzyl)-2,2'-ethanediyldiphenol

Base Information

• Chemical Name: 6,6'-dimethyl-4,4'-bis(3-bromo-4-hydroxy-5-tert-butylbenzyl)-2,2'-ethanediyldiphenol
• CAS No.: 197861-52-2
• Molecular Formula: C₃₈H₄₄Br₂O₄
• Molecular Weight: 724.573
• Mol file: 197861-52-2.mol

Synonyms:6,6'-dimethyl-4,4'-bis(3-bromo-4-hydroxy-5-tert-butylbenzyl)-2,2'-ethanediyldiphenol

Chemical Property of 6,6'-dimethyl-4,4'-bis(3-bromo-4-hydroxy-5-tert-butylbenzyl)-2,2'-ethanediyldiphenol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 6,6'-dimethyl-4,4'-bis(3-bromo-4-hydroxy-5-tert-butylbenzyl)-2,2'-ethanediyldiphenol

There total 2 articles about 6,6'-dimethyl-4,4'-bis(3-bromo-4-hydroxy-5-tert-butylbenzyl)-2,2'-ethanediyldiphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

2-bromo-6-(tert-butyl)phenol (23159-87-7) + 6,6'-dimethyl-4,4'-bis-(bromomethyl)-2,2'-ethanediyldiphenol (197861-50-0) → 6,6'-dimethyl-4,4'-bis(3-bromo-4-hydroxy-5-tert-butylbenzyl)-2,2'-ethanediyldiphenol (197861-52-2)

Guidance literature:

With zinc(II) carbonate; at 60 ℃; for 16h;

DOI:10.1021/jo970967u

Reference yield:

6,6'-dimethyl-2,2'-ethanediyldiphenol (197861-51-1) → 6,6'-dimethyl-4,4'-bis(3-bromo-4-hydroxy-5-tert-butylbenzyl)-2,2'-ethanediyldiphenol (197861-52-2)

Guidance literature:

Multi-step reaction with 2 steps

1: 57 percent / HBr / acetic acid

2: 51 percent / ZnCO₃ / 16 h / 60 °C

With hydrogen bromide; zinc(II) carbonate; In acetic acid; 1: Alkylation / 2: Alkylation;

DOI:10.1021/jo970967u

Reference yield: 88.0%

6,6'-dimethyl-4,4'-bis(3-bromo-4-hydroxy-5-tert-butylbenzyl)-2,2'-ethanediyldiphenol (197861-52-2) → 6,6'-dimethyl-4,4'-bis(3-tert-butyl-4-hydroxybenzyl)-2,2'-ethanediyldiphenol (197861-53-3)

Guidance literature:

With potassium hydroxide; hydrogen; nickel; In methanol; at 20 ℃;

DOI:10.1021/jo970967u

upstream raw materials:

2-bromo-6-(tert-butyl)phenol

6,6'-dimethyl-4,4'-bis-(bromomethyl)-2,2'-ethanediyldiphenol

6,6'-dimethyl-2,2'-ethanediyldiphenol

Downstream raw materials:

6,6'-dimethyl-4,4'-bis(3-tert-butyl-4-hydroxybenzyl)-2,2'-ethanediyldiphenol