2-Thiouridine

Base Information

Chemical Name:2-Thiouridine
CAS No.:20235-78-3
Molecular Formula:C9H12N2O5S
Molecular Weight:260.271
Hs Code.:
DSSTox Substance ID:DTXSID90174087
Nikkaji Number:J151.225K
Wikidata:Q20890502
Metabolomics Workbench ID:61251
Mol file:20235-78-3.mol

Synonyms:2-thiouridine

Suppliers and Price of 2-Thiouridine

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Usbiological
2-Thiouridine
50mg
$ 425.00

Usbiological
2-Thiouridine
50mg
$ 412.00

TRC
2-Thiouridine
500mg
$ 700.00

Medical Isotopes, Inc.
2-Thiouridine
0.5 g
$ 2000.00

Medical Isotopes, Inc.
2-Thiouridine
100 mg
$ 875.00

Chemenu
1-((2R,3R,4S,5R)-3,4-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)-2-thioxo-2,3-dihydropyrimidin-4(1H)-one 95%
1g
$ 1066.00

Cayman Chemical
2-Thiouridine ≥98%
500mg
$ 594.00

Cayman Chemical
2-Thiouridine ≥98%
250mg
$ 371.00

Cayman Chemical
2-Thiouridine ≥98%
50mg
$ 99.00

Cayman Chemical
2-Thiouridine ≥98%
100mg
$ 178.00

Total 42 raw suppliers

Chemical Property of 2-Thiouridine

Chemical Property:

Appearance/Colour:white solid
Melting Point:216-218 °C
Refractive Index:1.732
PKA:6.98±0.20(Predicted)
PSA：139.80000
Density:1.72 g/cm³
LogP:-1.48260
Storage Temp.:Refrigerator
Solubility.:DMSO (Slightly, Heated), Water (Slightly, Heated)
XLogP3:-1.4
Hydrogen Bond Donor Count:4
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:2
Exact Mass:260.04669266
Heavy Atom Count:17
Complexity:374

Purity/Quality:

97% ^*data from raw suppliers

2-Thiouridine ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:C1=CN(C(=S)NC1=O)C2C(C(C(O2)CO)O)O
Isomeric SMILES:C1=CN(C(=S)NC1=O)[C@H]2[C@@H]([C@@H]([C@H](O2)CO)O)O
Uses Modified nucleotide, essential for normal cell growth in some bacterial species. 2-THIOURIDINE is also able to chelate several metal ions.

Technology Process of 2-Thiouridine

There total 7 articles about 2-Thiouridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 13233-20-0,13239-97-9
2-thiocytidine

: 141-90-2,156-82-1
2-thiouracil

: 333-49-3
2-thiocytosine

: 20235-78-3
2-thiouridine

Guidance literature:: With formic acid; water; at 60 ℃; for 1296h; pH=3;
DOI:10.1038/nchem.2664

Reference yield: 33.0%

: 13233-20-0,13239-97-9
2-thiocytidine

: 20235-78-3
2-thiouridine

: 65-46-3
CYTIDINE

Guidance literature:: With water; In aq. phosphate buffer; at 60 ℃; for 2016h; pH=5;
DOI:10.1038/nchem.2664

Reference yield: 15.0%

5-O-(4,4-dimethoxytrityl)-2-O-tetrahydropyranyl-2-thiouridine-3-O-succinyl-NH(CH₂)11-Si(OEt)2-CPG: 5-O-(4,4-dimethoxytrityl)-2-O-tetrahydropyranyl-2-thiouridine-3-O-succinyl-NH(CH₂)11-Si(OEt)2-CPG

: 20235-78-3
2-thiouridine

: 21052-20-0
1-(β-D-ribofuranosyl)-4-pyrimidinone

: 58-96-8
uridine

Guidance literature:: 5\-O-(4,4\-dimethoxytrityl)-2\-O-tetrahydropyranyl-2-thiouridine-3\-O-succinyl-NH(CH₂)11-Si(OEt)2-CPG; With iodine; In pyridine; water; for 0.166667h;

With trichloroacetic acid; for 0.5h;

With ammonia; In ethanol; at 20 ℃; for 18h;
DOI:10.1081/NCN-100107198