methyl 2-[2-(cinnamoyl)amino-1-oxo-3-phenyl]propyl-amino-3-(2-oxo-3-pyrrolidinyl)-propionate

Base Information

Chemical Name:methyl 2-[2-(cinnamoyl)amino-1-oxo-3-phenyl]propyl-amino-3-(2-oxo-3-pyrrolidinyl)-propionate
CAS No.:1065478-35-4
Molecular Formula:C₂₆H₂₉N₃O₅
Molecular Weight:463.533
Hs Code.:

Synonyms:methyl 2-[2-(cinnamoyl)amino-1-oxo-3-phenyl]propyl-amino-3-(2-oxo-3-pyrrolidinyl)-propionate

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Chemical Property of methyl 2-[2-(cinnamoyl)amino-1-oxo-3-phenyl]propyl-amino-3-(2-oxo-3-pyrrolidinyl)-propionate

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Technology Process of methyl 2-[2-(cinnamoyl)amino-1-oxo-3-phenyl]propyl-amino-3-(2-oxo-3-pyrrolidinyl)-propionate

There total 2 articles about methyl 2-[2-(cinnamoyl)amino-1-oxo-3-phenyl]propyl-amino-3-(2-oxo-3-pyrrolidinyl)-propionate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: (S)-methyl 2-((S)-2-amino-3-phen-ylpropanamido)-3-((S)-2-oxopyrrolidin-3-yl)propanoate

: 102-92-1,17082-09-6
Cinnamoyl chloride

: 1065478-35-4
methyl 2-[2-(cinnamoyl)amino-1-oxo-3-phenyl]propyl-amino-3-(2-oxo-3-pyrrolidinyl)-propionate

Guidance literature:: With 4-methyl-morpholine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 5h;
DOI:10.1016/j.bmc.2008.06.015

Reference yield:

: 140-10-3
(E)-3-phenylacrylic acid

: C₁₇H₂₃N₃O₄*ClH

: 1065478-35-4
methyl 2-[2-(cinnamoyl)amino-1-oxo-3-phenyl]propyl-amino-3-(2-oxo-3-pyrrolidinyl)-propionate

Guidance literature:: (E)-3-phenylacrylic acid; C₁₇H₂₃N₃O₄*ClH; With N-[(dimethylamino)-3-oxo-1H-1,2,3-triazolo[4,5-b]pyridin-1-yl-methylene]-N-methylmethanaminium hexafluorophosphate; In dichloromethane; at -20 ℃; for 0.5h;

With N-ethyl-N,N-diisopropylamine; In dichloromethane; at -20 ℃; for 12h;
DOI:10.1021/acs.jmedchem.0c02258