methyl (2E)-3-(3-{(2R)-2-[(methoxymethoxy)methyl]-5-oxo-1-pyrrolidinyl}phenyl)acrylate

Base Information

Chemical Name:methyl (2E)-3-(3-{(2R)-2-[(methoxymethoxy)methyl]-5-oxo-1-pyrrolidinyl}phenyl)acrylate
CAS No.:1365177-21-4
Molecular Formula:C₁₇H₂₁NO₅
Molecular Weight:319.357
Hs Code.:

Synonyms:methyl (2E)-3-(3-{(2R)-2-[(methoxymethoxy)methyl]-5-oxo-1-pyrrolidinyl}phenyl)acrylate

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Chemical Property of methyl (2E)-3-(3-{(2R)-2-[(methoxymethoxy)methyl]-5-oxo-1-pyrrolidinyl}phenyl)acrylate

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Technology Process of methyl (2E)-3-(3-{(2R)-2-[(methoxymethoxy)methyl]-5-oxo-1-pyrrolidinyl}phenyl)acrylate

There total 2 articles about methyl (2E)-3-(3-{(2R)-2-[(methoxymethoxy)methyl]-5-oxo-1-pyrrolidinyl}phenyl)acrylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1365178-37-5
C₇H₁₃NO₃

: 79432-87-4
methyl m-bromocinnamate

: 1365177-21-4
methyl (2E)-3-(3-{(2R)-2-[(methoxymethoxy)methyl]-5-oxo-1-pyrrolidinyl}phenyl)acrylate

Guidance literature:: With 1,1'-bis-(diphenylphosphino)ferrocene; potassium tert-butylate; palladium diacetate; In 5,5-dimethyl-1,3-cyclohexadiene; at 140 ℃; for 6h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.02.018

Reference yield:

: 66673-40-3
(R)-5-hydroxymethylpyrrolidin-2-one

: 1365177-21-4
methyl (2E)-3-(3-{(2R)-2-[(methoxymethoxy)methyl]-5-oxo-1-pyrrolidinyl}phenyl)acrylate

Guidance literature:: Multi-step reaction with 2 steps

1: trifluorormethanesulfonic acid / dichloromethane / 6 h / 20 °C / Inert atmosphere

2: 1,1'-bis-(diphenylphosphino)ferrocene; potassium tert-butylate; palladium diacetate / 5,5-dimethyl-1,3-cyclohexadiene / 6 h / 140 °C / Inert atmosphere

With 1,1'-bis-(diphenylphosphino)ferrocene; trifluorormethanesulfonic acid; potassium tert-butylate; palladium diacetate; In 5,5-dimethyl-1,3-cyclohexadiene; dichloromethane;
DOI:10.1016/j.bmc.2012.02.018

Reference yield:

: 1365177-21-4
methyl (2E)-3-(3-{(2R)-2-[(methoxymethoxy)methyl]-5-oxo-1-pyrrolidinyl}phenyl)acrylate

: 1365178-43-3
C₁₇H₂₃NO₅

Guidance literature:: With sodium tetrahydroborate; nickel(II) chloride hexahydrate; In tetrahydrofuran; methanol; at 0 ℃; for 1h; Inert atmosphere;
DOI:10.1016/j.bmc.2012.02.018