N-[(1S,3R)-5-(3,5-difluorobenzyl)-1,4-dioxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl]-(6E)-(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide

Base Information

Chemical Name:N-[(1S,3R)-5-(3,5-difluorobenzyl)-1,4-dioxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl]-(6E)-(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide
CAS No.:958489-27-5
Molecular Formula:C₂₈H₃₄F₂N₂O₇S
Molecular Weight:580.65
Hs Code.:

N-[(1S,3R)-5-(3,5-difluorobenzyl)-1,4-dioxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl]-(6E)-(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide

Synonyms:N-[(1S,3R)-5-(3,5-difluorobenzyl)-1,4-dioxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl]-(6E)-(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide

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Chemical Property of N-[(1S,3R)-5-(3,5-difluorobenzyl)-1,4-dioxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl]-(6E)-(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide

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Technology Process of N-[(1S,3R)-5-(3,5-difluorobenzyl)-1,4-dioxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl]-(6E)-(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide

There total 6 articles about N-[(1S,3R)-5-(3,5-difluorobenzyl)-1,4-dioxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl]-(6E)-(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 958489-30-0
N-[(3R)-5-(3,5-difluorobenzyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl]-(6E)-(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide

: 958489-26-4
N-[(1R,3R)-5-(3,5-difluorobenzyl)-1,4-dioxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl]-(6E)-(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide

: 958489-27-5
N-[(1S,3R)-5-(3,5-difluorobenzyl)-1,4-dioxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl]-(6E)-(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide

Guidance literature:: With 1,1,1,3',3',3'-hexafluoro-propanol; dihydrogen peroxide; In water; at 20 ℃; for 29h;

Reference yield:

: 958489-28-6
tert-butyl (3R)-[5-(3,5-difluorobenzyl)-4-oxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl]carbamate

: 958489-26-4
N-[(1R,3R)-5-(3,5-difluorobenzyl)-1,4-dioxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl]-(6E)-(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide

: 958489-27-5
N-[(1S,3R)-5-(3,5-difluorobenzyl)-1,4-dioxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl]-(6E)-(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide

Guidance literature:: Multi-step reaction with 3 steps

1: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C

2: sodium 2-ethylhexanoic acid / tetrahydrofuran / 24 h / 20 °C

3: 1,1,1,3',3',3'-hexafluoro-propanol; dihydrogen peroxide / water / 29 h / 20 °C

With hydrogenchloride; 1,1,1,3',3',3'-hexafluoro-propanol; dihydrogen peroxide; sodium 2-ethylhexanoic acid; In tetrahydrofuran; 1,4-dioxane; water;

Reference yield:

: 141776-91-2
1-bromomethyl-3,5-difluoro-benzene

: 958489-26-4
N-[(1R,3R)-5-(3,5-difluorobenzyl)-1,4-dioxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl]-(6E)-(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide

: 958489-27-5
N-[(1S,3R)-5-(3,5-difluorobenzyl)-1,4-dioxo-2,3,4,5-tetrahydro-1,5-benzothiazepin-3-yl]-(6E)-(2R,3R,4S,5R)-3,4,5-trihydroxy-2-methoxy-8,8-dimethylnon-6-enamide

Guidance literature:: Multi-step reaction with 4 steps

1: sodium hydride / tetrahydrofuran / 1 h / 20 °C

2: hydrogenchloride / 1,4-dioxane / 5 h / 20 °C

3: sodium 2-ethylhexanoic acid / tetrahydrofuran / 24 h / 20 °C

4: 1,1,1,3',3',3'-hexafluoro-propanol; dihydrogen peroxide / water / 29 h / 20 °C

With hydrogenchloride; 1,1,1,3',3',3'-hexafluoro-propanol; dihydrogen peroxide; sodium hydride; sodium 2-ethylhexanoic acid; In tetrahydrofuran; 1,4-dioxane; water;