(2S,4S)-5-Biphenyl-4-yl-4-[(3-hydroxy-isoxazole-5-carbonyl)-amino]-2-hydroxymethyl-5-methyl-hexanoic Acid

Base Information

Chemical Name:(2S,4S)-5-Biphenyl-4-yl-4-[(3-hydroxy-isoxazole-5-carbonyl)-amino]-2-hydroxymethyl-5-methyl-hexanoic Acid
CAS No.:1394050-08-8
Molecular Formula:C₂₄H₂₆N₂O₆
Molecular Weight:438.48
Hs Code.:

Synonyms:(2S,4S)-5-Biphenyl-4-yl-4-[(3-hydroxy-isoxazole-5-carbonyl)-amino]-2-hydroxymethyl-5-methyl-hexanoic Acid

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Chemical Property of (2S,4S)-5-Biphenyl-4-yl-4-[(3-hydroxy-isoxazole-5-carbonyl)-amino]-2-hydroxymethyl-5-methyl-hexanoic Acid

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Technology Process of (2S,4S)-5-Biphenyl-4-yl-4-[(3-hydroxy-isoxazole-5-carbonyl)-amino]-2-hydroxymethyl-5-methyl-hexanoic Acid

There total 5 articles about (2S,4S)-5-Biphenyl-4-yl-4-[(3-hydroxy-isoxazole-5-carbonyl)-amino]-2-hydroxymethyl-5-methyl-hexanoic Acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 13626-60-3
3-hydroxy-1,2-oxazole-5-carboxylic acid

: 1394050-41-9
(2S,4S)-4-amino-5-biphenyl-4-yl-2-hydroxymethyl-5-methylhexanoic acid ethyl ester hydrochloride

: 1310-65-2
lithium hydroxide

: 1394050-08-8
(2S,4S)-5-Biphenyl-4-yl-4-[(3-hydroxy-isoxazole-5-carbonyl)-amino]-2-hydroxymethyl-5-methyl-hexanoic Acid

Guidance literature:: 3-hydroxy-1,2-oxazole-5-carboxylic acid; lithium hydroxide; With HATU; In N,N-dimethyl-formamide; for 0.0833333h; Inert atmosphere;

(2S,4S)-4-amino-5-biphenyl-4-yl-2-hydroxymethyl-5-methylhexanoic acid ethyl ester hydrochloride; With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; at 20 ℃; for 0.333333h; Inert atmosphere;

Reference yield:

: 1394050-37-3
C₂₇H₃₄N₂O₃

: 1394050-08-8
(2S,4S)-5-Biphenyl-4-yl-4-[(3-hydroxy-isoxazole-5-carbonyl)-amino]-2-hydroxymethyl-5-methyl-hexanoic Acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride / water; tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

2.1: acetic acid / ethanol; tetrahydrofuran / 0.5 h / -5 °C / Inert atmosphere

2.2: 2 h / -5 °C / Inert atmosphere

3.1: potassium carbonate / ethanol / 0 - 20 °C / Inert atmosphere

4.1: hydrogenchloride / ethanol / 3 h / 20 °C

5.1: HATU / N,N-dimethyl-formamide / 0.08 h / Inert atmosphere

5.2: 0.33 h / 20 °C / Inert atmosphere

With hydrogenchloride; potassium carbonate; acetic acid; HATU; In tetrahydrofuran; ethanol; water; N,N-dimethyl-formamide;

Reference yield:

: 1394050-38-4
C₂₅H₂₉NO₄

: 1394050-08-8
(2S,4S)-5-Biphenyl-4-yl-4-[(3-hydroxy-isoxazole-5-carbonyl)-amino]-2-hydroxymethyl-5-methyl-hexanoic Acid

Guidance literature:: Multi-step reaction with 4 steps

1.1: acetic acid / ethanol; tetrahydrofuran / 0.5 h / -5 °C / Inert atmosphere

1.2: 2 h / -5 °C / Inert atmosphere

2.1: potassium carbonate / ethanol / 0 - 20 °C / Inert atmosphere

3.1: hydrogenchloride / ethanol / 3 h / 20 °C

4.1: HATU / N,N-dimethyl-formamide / 0.08 h / Inert atmosphere

4.2: 0.33 h / 20 °C / Inert atmosphere

With hydrogenchloride; potassium carbonate; acetic acid; HATU; In tetrahydrofuran; ethanol; N,N-dimethyl-formamide;