N⁴-benzoyl-1-{2'-O-acetyl-3'-O-[(4',4''-dimethoxytriphenyl)methyl]-α-L-threofuranosyl}cytosine

Base Information

• Chemical Name: N⁴-benzoyl-1-{2'-O-acetyl-3'-O-[(4',4''-dimethoxytriphenyl)methyl]-α-L-threofuranosyl}cytosine
• CAS No.: 851346-32-2
• Molecular Formula: C₃₈H₃₅N₃O₈
• Molecular Weight: 661.711

Synonyms:N⁴-benzoyl-1-{2'-O-acetyl-3'-O-[(4',4''-dimethoxytriphenyl)methyl]-α-L-threofuranosyl}cytosine

Chemical Property of N⁴-benzoyl-1-{2'-O-acetyl-3'-O-[(4',4''-dimethoxytriphenyl)methyl]-α-L-threofuranosyl}cytosine

Chemical Property:

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Technology Process of N⁴-benzoyl-1-{2'-O-acetyl-3'-O-[(4',4''-dimethoxytriphenyl)methyl]-α-L-threofuranosyl}cytosine

There total 1 articles about N⁴-benzoyl-1-{2'-O-acetyl-3'-O-[(4',4''-dimethoxytriphenyl)methyl]-α-L-threofuranosyl}cytosine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

acetic anhydride (108-24-7) + N4-benzoyl-1-{3'-O-[(4,4'-dimethoxytriphenyl)methyl]-α-L-threofuranosyl}cytosine (325683-91-8) → N4-benzoyl-1-{2'-O-acetyl-3'-O-[(4',4''-dimethoxytriphenyl)methyl]-α-L-threofuranosyl}cytosine (851346-32-2)

Guidance literature:

With pyridine; at 20 ℃; for 12h;

DOI:10.1021/ol050081+

Reference yield: 92.0%

N4-benzoyl-1-{2'-O-acetyl-3'-O-[(4',4''-dimethoxytriphenyl)methyl]-α-L-threofuranosyl}cytosine (851346-32-2) → N4-benzoyl-1-{2'-O-acetyl-α-L-threofuranosyl}cytosine (851346-33-3)

Guidance literature:

With trichloroacetic acid; In dichloromethane; at 20 ℃; for 0.05h;

DOI:10.1021/ol050081+

Reference yield:

N4-benzoyl-1-{2'-O-acetyl-3'-O-[(4',4''-dimethoxytriphenyl)methyl]-α-L-threofuranosyl}cytosine (851346-32-2) → C17H17N3O15P3(3-)

Guidance literature:

Multi-step reaction with 2 steps

1.1: 92 percent / trichloroacetic acid / CH₂Cl₂ / 0.05 h / 20 °C

2.1: 2-chloro-4H-1,3,2-benzodiazaphosphorin-4-one; pyridine / dioxane / 0.33 h

2.2: tributylammonium pyrophosphate; tributylamine / dioxane; dimethylformamide / 0.25 h

2.3: I₂; pyridine; sodium sulfite / dioxane; dimethylformamide; H₂O

With pyridine; 2-chloro-4H-1,3,2-benzodiazaphosphorin-4-one; trichloroacetic acid; In 1,4-dioxane; dichloromethane;

DOI:10.1021/ol050081+

upstream raw materials:

acetic anhydride

N⁴-benzoyl-1-{3'-O-[(4,4'-dimethoxytriphenyl)methyl]-α-L-threofuranosyl}cytosine

Downstream raw materials:

N⁴-benzoyl-1-{2'-O-acetyl-α-L-threofuranosyl}cytosine

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