(4S)-benzyl-3-[(2'R)-(4-fluorophenyl)propionyl-3'-benzyloxy]-2-oxazolidinone

Base Information

Chemical Name:(4S)-benzyl-3-[(2'R)-(4-fluorophenyl)propionyl-3'-benzyloxy]-2-oxazolidinone
CAS No.:637357-00-7
Molecular Formula:C₂₆H₂₄FNO₄
Molecular Weight:433.479
Hs Code.:

Synonyms:(4S)-benzyl-3-[(2'R)-(4-fluorophenyl)propionyl-3'-benzyloxy]-2-oxazolidinone

Suppliers and Price of (4S)-benzyl-3-[(2'R)-(4-fluorophenyl)propionyl-3'-benzyloxy]-2-oxazolidinone

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (4S)-benzyl-3-[(2'R)-(4-fluorophenyl)propionyl-3'-benzyloxy]-2-oxazolidinone

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Technology Process of (4S)-benzyl-3-[(2'R)-(4-fluorophenyl)propionyl-3'-benzyloxy]-2-oxazolidinone

There total 1 articles about (4S)-benzyl-3-[(2'R)-(4-fluorophenyl)propionyl-3'-benzyloxy]-2-oxazolidinone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 3587-60-8
Benzyloxymethyl chloride

: 159707-16-1
(4S)-benzyl-3-[2'-(4-fluorophenyl)acetyl]-2-oxazolidinone

: 637357-00-7
(4S)-benzyl-3-[(2'R)-(4-fluorophenyl)propionyl-3'-benzyloxy]-2-oxazolidinone

Guidance literature:: (4S)-benzyl-3-[2'-(4-fluorophenyl)acetyl]-2-oxazolidinone; With titanium tetrachloride; N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 1h;

Benzyloxymethyl chloride; In dichloromethane; at 0 ℃; for 12h;
DOI:10.1021/ja0382361

Reference yield: 62.0%

: 637357-00-7
(4S)-benzyl-3-[(2'R)-(4-fluorophenyl)propionyl-3'-benzyloxy]-2-oxazolidinone

: 637357-02-9
3-benzyloxy-(2S)-(4-fluorophenyl)propan-1-ol

Guidance literature:: With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 ℃; for 0.583333h;
DOI:10.1021/ja0382361

Reference yield:

: 637357-00-7
(4S)-benzyl-3-[(2'R)-(4-fluorophenyl)propionyl-3'-benzyloxy]-2-oxazolidinone

: 637357-07-4
3-bromo-(2R)-(4-fluorophenyl)propan-1-ol

Guidance literature:: Multi-step reaction with 3 steps

1: 62 percent / LAH / tetrahydrofuran / 0.58 h / 0 °C

2: 75 percent / CBr₄; PPh₃ / CH₂Cl₂ / 24 h / 20 °C

3: 90 percent / H₂ / Pd/C / tetrahydrofuran / 5 h

With lithium aluminium tetrahydride; carbon tetrabromide; hydrogen; triphenylphosphine; palladium on activated charcoal; In tetrahydrofuran; dichloromethane;
DOI:10.1021/ja0382361