4-(5-((2,6-difluorobenzyl)thio)-1,3,4-oxadiazol-2-yl)-2-methoxyphenol

Base Information

Chemical Name:4-(5-((2,6-difluorobenzyl)thio)-1,3,4-oxadiazol-2-yl)-2-methoxyphenol
CAS No.:1398647-66-9
Molecular Formula:C₁₆H₁₂F₂N₂O₃S
Molecular Weight:350.346
Hs Code.:

Synonyms:4-(5-((2,6-difluorobenzyl)thio)-1,3,4-oxadiazol-2-yl)-2-methoxyphenol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(5-((2,6-difluorobenzyl)thio)-1,3,4-oxadiazol-2-yl)-2-methoxyphenol

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Technology Process of 4-(5-((2,6-difluorobenzyl)thio)-1,3,4-oxadiazol-2-yl)-2-methoxyphenol

There total 2 articles about 4-(5-((2,6-difluorobenzyl)thio)-1,3,4-oxadiazol-2-yl)-2-methoxyphenol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 73.0%

: 85118-00-9
2,6-Difluorobenzyl bromide

: 1391739-44-8
C₉H₈N₂O₃S

: 1398647-66-9
4-(5-((2,6-difluorobenzyl)thio)-1,3,4-oxadiazol-2-yl)-2-methoxyphenol

Guidance literature:: With potassium hydroxide; In acetonitrile; at 85 ℃; for 3h;
DOI:10.1016/j.bmc.2012.05.055

Reference yield:

: 617-05-0
ethyl vanillate

: 1398647-66-9
4-(5-((2,6-difluorobenzyl)thio)-1,3,4-oxadiazol-2-yl)-2-methoxyphenol

Guidance literature:: Multi-step reaction with 3 steps

1: hydrazine hydrate / ethanol / 20 h / Reflux

2: potassium hydroxide / ethanol / 20 h / Reflux

3: potassium hydroxide / acetonitrile / 3 h / 85 °C

With hydrazine hydrate; potassium hydroxide; In ethanol; acetonitrile;
DOI:10.1016/j.bmc.2012.05.055