{(3aR,4R,6S,6aS)-2,2-Dimethyl-6-[2-(5-phenyl-tetrazol-2-yl)-ethyl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-methanol

Base Information

Chemical Name:{(3aR,4R,6S,6aS)-2,2-Dimethyl-6-[2-(5-phenyl-tetrazol-2-yl)-ethyl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-methanol
CAS No.:453560-23-1
Molecular Formula:C₁₇H₂₂N₄O₄
Molecular Weight:346.386
Hs Code.:

Synonyms:{(3aR,4R,6S,6aS)-2,2-Dimethyl-6-[2-(5-phenyl-tetrazol-2-yl)-ethyl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-methanol

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Chemical Property of {(3aR,4R,6S,6aS)-2,2-Dimethyl-6-[2-(5-phenyl-tetrazol-2-yl)-ethyl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-methanol

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Technology Process of {(3aR,4R,6S,6aS)-2,2-Dimethyl-6-[2-(5-phenyl-tetrazol-2-yl)-ethyl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-methanol

There total 10 articles about {(3aR,4R,6S,6aS)-2,2-Dimethyl-6-[2-(5-phenyl-tetrazol-2-yl)-ethyl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: 1416466-03-9
C₃₇H₃₈N₄O₅

: 453560-23-1
{(3aR,4R,6S,6aS)-2,2-Dimethyl-6-[2-(5-phenyl-tetrazol-2-yl)-ethyl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-methanol

Guidance literature:: With acetic acid; In diethyl ether; at 55 ℃; for 10h;
DOI:10.1002/cbic.201200174

Reference yield:

: 2-{2-[6-(tert-butyl-dimethyl-silanyloxymethyl)-2,2-dimethyl-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl]-ethyl}-5-phenyl-2H-tetrazole

: 453560-23-1
{(3aR,4R,6S,6aS)-2,2-Dimethyl-6-[2-(5-phenyl-tetrazol-2-yl)-ethyl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-methanol

Guidance literature:: With tetrabutyl ammonium fluoride; In tetrahydrofuran;
DOI:10.1016/S0960-894X(01)00095-6

Reference yield:

: 55036-19-6
methyl [(3aS,4S,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl]acetate

: 453560-23-1
{(3aR,4R,6S,6aS)-2,2-Dimethyl-6-[2-(5-phenyl-tetrazol-2-yl)-ethyl]-tetrahydro-furo[3,4-d][1,3]dioxol-4-yl}-methanol

Guidance literature:: Multi-step reaction with 4 steps

1: 97 percent / imidazole / tetrahydrofuran

2: 77 percent / LiAlH₄ / tetrahydrofuran

3: DEAD; PPh₃ / tetrahydrofuran

4: Bu₄NF / tetrahydrofuran

With 1H-imidazole; lithium aluminium tetrahydride; tetrabutyl ammonium fluoride; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; 3: Mitsunobu reaction;
DOI:10.1016/S0960-894X(01)00095-6