(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl-(S)-α-hydroxy-α-<4-(2-fluoroethyl)phenyl>benzeneacetate

Base Information

• Chemical Name: (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl-(S)-α-hydroxy-α-<4-(2-fluoroethyl)phenyl>benzeneacetate
• CAS No.: 153993-89-6
• Molecular Formula: C₃₂H₃₇FO₃
• Molecular Weight: 488.642
• Mol file: 153993-89-6.mol

Synonyms:(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl-(S)-α-hydroxy-α-<4-(2-fluoroethyl)phenyl>benzeneacetate

Chemical Property of (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl-(S)-α-hydroxy-α-<4-(2-fluoroethyl)phenyl>benzeneacetate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl-(S)-α-hydroxy-α-<4-(2-fluoroethyl)phenyl>benzeneacetate

There total 5 articles about (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl-(S)-α-hydroxy-α-<4-(2-fluoroethyl)phenyl>benzeneacetate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

phenylglyoxylyl chloride (25726-04-9) → (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl-(S)-α-hydroxy-α-<4-(2-fluoroethyl)phenyl>benzeneacetate (153993-89-6)

Guidance literature:

Multi-step reaction with 2 steps

1: Et₃N / CH₂Cl₂ / 0 - 20 °C

2: 1.) Mg, I₂ / 1.) THF, sonication, 30 min, 2.) THF, a.) -78 deg C, 40 min, b.) 90 min

With iodine; magnesium; triethylamine; In dichloromethane;

DOI:10.1016/S0957-4166(00)80069-5

Reference yield:

4-bromophenethanol (4654-39-1) → (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl-(S)-α-hydroxy-α-<4-(2-fluoroethyl)phenyl>benzeneacetate (153993-89-6)

Guidance literature:

Multi-step reaction with 3 steps

1: pyridine / CH₂Cl₂ / 2 h / 0 °C

2: Me₄NFHF / acetonitrile / 1 h / Ambient temperature

3: 1.) Mg, I₂ / 1.) THF, sonication, 30 min, 2.) THF, a.) -78 deg C, 40 min, b.) 90 min

With pyridine; iodine; magnesium; tetramethylammonium hydrogen difluoride; In dichloromethane; acetonitrile;

DOI:10.1016/S0957-4166(00)80069-5

Reference yield:

Benzoylformic acid (611-73-4) → (1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)cyclohexyl-(S)-α-hydroxy-α-<4-(2-fluoroethyl)phenyl>benzeneacetate (153993-89-6)

Guidance literature:

Multi-step reaction with 3 steps

1: Cl₂CHOCH₃ / 1 h / 50 °C

2: Et₃N / CH₂Cl₂ / 0 - 20 °C

3: 1.) Mg, I₂ / 1.) THF, sonication, 30 min, 2.) THF, a.) -78 deg C, 40 min, b.) 90 min

With Dichloromethyl methyl ether; iodine; magnesium; triethylamine; In dichloromethane;

DOI:10.1016/S0957-4166(00)80069-5

upstream raw materials:

1-bromo-4-(2-fluoroethyl)benzene

Phenylglyoxylsaeure-<(1R,2S,5R)-5-methyl-2-(1-methyl-1-phenylethyl)-1-cyclohexyl>ester

phenylglyoxylyl chloride

4-bromophenethanol

Downstream raw materials:

(S)-α-hydroxy-α-<4-(2-fluoroethyl)phenyl>benzeneacetic acid