[N-3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl-N-hydroxylamine

Base Information

Chemical Name:[N-3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl-N-hydroxylamine
CAS No.:503026-32-2
Molecular Formula:C₁₄H₁₈FN₃O₄
Molecular Weight:311.313
Hs Code.:

Synonyms:[N-3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl-N-hydroxylamine

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of [N-3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl-N-hydroxylamine

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Technology Process of [N-3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl-N-hydroxylamine

There total 6 articles about [N-3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl-N-hydroxylamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 174649-09-3,2180621-71-8
(R)-methyl methanesulfonate

: 503026-32-2
[N-3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl-N-hydroxylamine

Guidance literature:: Multi-step reaction with 2 steps

1: 70 percent / NaH / dimethylformamide / 48 h / 20 °C

2: 58 percent / TFA / CH₂Cl₂ / 2.5 h / 0 °C

With sodium hydride; trifluoroacetic acid; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1016/S0968-0896(02)00423-6

Reference yield:

: 369-34-6
3,4-difluoronitrobenzene

: 503026-32-2
[N-3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl-N-hydroxylamine

Guidance literature:: Multi-step reaction with 7 steps

1.1: N-ethyl-N,N-diisopropylamine / ethyl acetate / 20 °C

2.1: ammonium formate; palladium 10% on activated carbon / methanol; tetrahydrofuran

3.1: acetone; water / 20 °C

4.1: n-butyllithium / tetrahydrofuran / -78 °C

5.1: triethylamine / dichloromethane / 0 - 20 °C

6.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

6.2: 64 h / 0 - 20 °C

7.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

With n-butyllithium; palladium 10% on activated carbon; ammonium formate; sodium hydride; triethylamine; N-ethyl-N,N-diisopropylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; ethyl acetate; N,N-dimethyl-formamide; acetone; mineral oil;
DOI:10.1016/j.ejmech.2015.10.025

Reference yield:

: 2689-39-6
3-fluoro-4-(4-morpholinyl)nitrobenzene

: 503026-32-2
[N-3-(3-fluoro-4-morpholinylphenyl)-2-oxo-5-oxazolidinyl]methyl-N-hydroxylamine

Guidance literature:: Multi-step reaction with 6 steps

1.1: ammonium formate; palladium 10% on activated carbon / methanol; tetrahydrofuran

2.1: acetone; water / 20 °C

3.1: n-butyllithium / tetrahydrofuran / -78 °C

4.1: triethylamine / dichloromethane / 0 - 20 °C

5.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 °C / Inert atmosphere

5.2: 64 h / 0 - 20 °C

6.1: trifluoroacetic acid / dichloromethane / 0 - 20 °C

With n-butyllithium; palladium 10% on activated carbon; ammonium formate; sodium hydride; triethylamine; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane; water; N,N-dimethyl-formamide; acetone; mineral oil;
DOI:10.1016/j.ejmech.2015.10.025