Technology Process of 5-((3aS,4S,6aR)-2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl)-pentanoic acid 2-[4-(2,4-dioxo-thiazolidin-5-ylmethyl)-phenoxymethyl]-2,5,7,8-tetramethyl-chroman-6-yl ester
There total 7 articles about 5-((3aS,4S,6aR)-2-oxo-hexahydro-thieno[3,4-d]imidazol-4-yl)-pentanoic acid 2-[4-(2,4-dioxo-thiazolidin-5-ylmethyl)-phenoxymethyl]-2,5,7,8-tetramethyl-chroman-6-yl ester which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
biotin;
With
triethylamine;
In
dichloromethane; N,N-dimethyl-formamide;
for 0.75h;
Cooling with ice;
Inert atmosphere;
Troglitazone;
With
dmap;
In
dichloromethane; N,N-dimethyl-formamide;
at 20 ℃;
for 12h;
DOI:10.1016/j.ejmech.2012.02.044
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
2.1: pyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
3.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 2 °C / Inert atmosphere
4.1: piperidine / ethanol / 12 h / Inert atmosphere; Reflux
5.1: palladium 10% on activated carbon; hydrogen / 1,4-dioxane / 20 h / 20 °C / 3620.13 Torr
6.1: hydrogenchloride; water / acetonitrile / 0.75 h / Reflux
7.1: triethylamine / dichloromethane; N,N-dimethyl-formamide / 0.75 h / Cooling with ice; Inert atmosphere
7.2: 12 h / 20 °C
With
piperidine; pyridine; hydrogenchloride; lithium aluminium tetrahydride; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; triethylamine;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2012.02.044
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: toluene-4-sulfonic acid / 12 h / Reflux
2.1: dmap / dichloromethane / 2 h / 20 °C / Inert atmosphere
3.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 20 °C / Inert atmosphere
4.1: pyridine / dichloromethane / 0.5 h / 0 °C / Inert atmosphere
5.1: potassium carbonate / N,N-dimethyl-formamide / 48 h / 2 °C / Inert atmosphere
6.1: piperidine / ethanol / 12 h / Inert atmosphere; Reflux
7.1: palladium 10% on activated carbon; hydrogen / 1,4-dioxane / 20 h / 20 °C / 3620.13 Torr
8.1: hydrogenchloride; water / acetonitrile / 0.75 h / Reflux
9.1: triethylamine / dichloromethane; N,N-dimethyl-formamide / 0.75 h / Cooling with ice; Inert atmosphere
9.2: 12 h / 20 °C
With
piperidine; pyridine; hydrogenchloride; dmap; lithium aluminium tetrahydride; palladium 10% on activated carbon; water; hydrogen; potassium carbonate; toluene-4-sulfonic acid; triethylamine;
In
tetrahydrofuran; 1,4-dioxane; ethanol; dichloromethane; N,N-dimethyl-formamide; acetonitrile;
DOI:10.1016/j.ejmech.2012.02.044
