Technology Process of 11-deoxy-11-(carboxybenzylamino)-6-O-methylerythromycin A 11,12-(cyclic ester)
There total 6 articles about 11-deoxy-11-(carboxybenzylamino)-6-O-methylerythromycin A 11,12-(cyclic ester) which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
methanol;
for 2h;
under 3040 Torr;
Yield given;
Ambient temperature;
DOI:10.1021/jo00245a038
- Guidance literature:
-
Multi-step reaction with 6 steps
1: 73 percent / triethylamine / CH2Cl2 / 5.5 h
2: 87 percent / (dimethylamino)pyridine (DMAP) / CH2Cl2 / 1.) -40 deg C, 1 h, 2.) -20 deg C, 72 h
3: 1.) sodium bis(trimethylsilyl)amide / 1.) THF, -40 deg C, 2.5 h, 2.) DMF, 18 h
4: 84 percent / H2O; acetonitrile / 4.5 h
5: MeOH / 96 h / Ambient temperature
6: H2 / Pd/C / methanol / 2 h / 3040 Torr / Ambient temperature
With
methanol; dmap; hydrogen; sodium hexamethyldisilazane; triethylamine;
palladium on activated charcoal;
In
methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jo00245a038
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 87 percent / (dimethylamino)pyridine (DMAP) / CH2Cl2 / 1.) -40 deg C, 1 h, 2.) -20 deg C, 72 h
2: 1.) sodium bis(trimethylsilyl)amide / 1.) THF, -40 deg C, 2.5 h, 2.) DMF, 18 h
3: 84 percent / H2O; acetonitrile / 4.5 h
4: MeOH / 96 h / Ambient temperature
5: H2 / Pd/C / methanol / 2 h / 3040 Torr / Ambient temperature
With
methanol; dmap; hydrogen; sodium hexamethyldisilazane;
palladium on activated charcoal;
In
methanol; dichloromethane; water; acetonitrile;
DOI:10.1021/jo00245a038
