3-(3-iodo-4-isopropoxyphenyl)-5-(4-n-butyl-3-chlorophenyl)-1,2,4-oxadiazole

Base Information

Chemical Name:3-(3-iodo-4-isopropoxyphenyl)-5-(4-n-butyl-3-chlorophenyl)-1,2,4-oxadiazole
CAS No.:1608148-02-2
Molecular Formula:C₂₁H₂₂ClIN₂O₂
Molecular Weight:496.775
Hs Code.:

Synonyms:3-(3-iodo-4-isopropoxyphenyl)-5-(4-n-butyl-3-chlorophenyl)-1,2,4-oxadiazole

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 3-(3-iodo-4-isopropoxyphenyl)-5-(4-n-butyl-3-chlorophenyl)-1,2,4-oxadiazole

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Technology Process of 3-(3-iodo-4-isopropoxyphenyl)-5-(4-n-butyl-3-chlorophenyl)-1,2,4-oxadiazole

There total 7 articles about 3-(3-iodo-4-isopropoxyphenyl)-5-(4-n-butyl-3-chlorophenyl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 49.0%

: 1608146-89-9
3-chloro-N'-(3-iodo-4-isopropoxybenzoyl)-4-propoxybenzohydrazide

: 54256-44-9
4-n-butyl-3-chlorobenzoyl chloride

: 1608148-02-2
3-(3-iodo-4-isopropoxyphenyl)-5-(4-n-butyl-3-chlorophenyl)-1,2,4-oxadiazole

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In tetrahydrofuran; at 0 - 20 ℃; for 2h; Inert atmosphere;

Reference yield:

: 117738-74-6
methyl 4-bromo-3-chlorobenzoate

: 1608148-02-2
3-(3-iodo-4-isopropoxyphenyl)-5-(4-n-butyl-3-chlorophenyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: zinc dibromide / tetrahydrofuran; cyclohexane / 0.5 h / -78 - 20 °C / Inert atmosphere

1.2: 2 h / -78 - 20 °C / Inert atmosphere

2.1: potassium hydroxide; water / 1,4-dioxane / Reflux

3.1: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 1 h / 20 °C

4.1: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

With oxalyl dichloride; water; N-ethyl-N,N-diisopropylamine; potassium hydroxide; zinc dibromide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; cyclohexane; N,N-dimethyl-formamide;

Reference yield:

: 1608147-96-1
methyl 4-n-butyl-3-chlorobenzoate

: 1608148-02-2
3-(3-iodo-4-isopropoxyphenyl)-5-(4-n-butyl-3-chlorophenyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 3 steps

1: potassium hydroxide; water / 1,4-dioxane / Reflux

2: oxalyl dichloride / N,N-dimethyl-formamide; dichloromethane / 1 h / 20 °C

3: N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 2 h / 0 - 20 °C / Inert atmosphere

With oxalyl dichloride; water; N-ethyl-N,N-diisopropylamine; potassium hydroxide; In tetrahydrofuran; 1,4-dioxane; dichloromethane; N,N-dimethyl-formamide;