(2S,5S)-5-(tert-butyldimethylsilyloxy)-2-(p-methoxybenzyloxy)-6-methyl-3-heptanone

Base Information

Chemical Name:(2S,5S)-5-(tert-butyldimethylsilyloxy)-2-(p-methoxybenzyloxy)-6-methyl-3-heptanone
CAS No.:1415121-82-2
Molecular Formula:C₂₂H₃₈O₄Si
Molecular Weight:394.627
Hs Code.:

Synonyms:(2S,5S)-5-(tert-butyldimethylsilyloxy)-2-(p-methoxybenzyloxy)-6-methyl-3-heptanone

Suppliers and Price of (2S,5S)-5-(tert-butyldimethylsilyloxy)-2-(p-methoxybenzyloxy)-6-methyl-3-heptanone

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (2S,5S)-5-(tert-butyldimethylsilyloxy)-2-(p-methoxybenzyloxy)-6-methyl-3-heptanone

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (2S,5S)-5-(tert-butyldimethylsilyloxy)-2-(p-methoxybenzyloxy)-6-methyl-3-heptanone

There total 3 articles about (2S,5S)-5-(tert-butyldimethylsilyloxy)-2-(p-methoxybenzyloxy)-6-methyl-3-heptanone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 1058681-85-8
(2S,5S)-5-hydroxy-2-((4-methoxybenzyl)oxy)-6-methylheptan-3-one

: 69739-34-0
t-butyldimethylsiyl triflate

: 1415121-82-2
(2S,5S)-5-(tert-butyldimethylsilyloxy)-2-(p-methoxybenzyloxy)-6-methyl-3-heptanone

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1016/j.tet.2012.09.096 DOI:10.1016/j.tet.2012.09.096

Reference yield:

: 1058681-56-3
(S)-3-((4-methoxybenzyl)oxy)butan-2-one

: 1415121-82-2
(2S,5S)-5-(tert-butyldimethylsilyloxy)-2-(p-methoxybenzyloxy)-6-methyl-3-heptanone

Guidance literature:: Multi-step reaction with 2 steps

1.1: titanium(IV) trichloride isopropoxide / dichloromethane / 0.08 h / -78 °C / Inert atmosphere

1.2: 0.5 h / -78 °C / Inert atmosphere

1.3: 0.5 h / -78 °C / Inert atmosphere

2.1: 2,6-dimethylpyridine / dichloromethane / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; titanium(IV) trichloride isopropoxide; In dichloromethane; 1.3: |Aldol Addition;
DOI:10.1016/j.tet.2012.09.096 DOI:10.1016/j.tet.2012.09.096

Reference yield:

: (S)-2-((4-methoxybenzyl)oxy)-1-(pyrrolidin-1-yl)propan-1-one

: 1415121-82-2
(2S,5S)-5-(tert-butyldimethylsilyloxy)-2-(p-methoxybenzyloxy)-6-methyl-3-heptanone

Guidance literature:: Multi-step reaction with 3 steps

1.1: diethyl ether; tetrahydrofuran / 0.08 h / -78 °C / Inert atmosphere

2.1: titanium(IV) trichloride isopropoxide / dichloromethane / 0.08 h / -78 °C / Inert atmosphere

2.2: 0.5 h / -78 °C / Inert atmosphere

2.3: 0.5 h / -78 °C / Inert atmosphere

3.1: 2,6-dimethylpyridine / dichloromethane / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; titanium(IV) trichloride isopropoxide; In tetrahydrofuran; diethyl ether; dichloromethane; 2.3: |Aldol Addition;
DOI:10.1016/j.tet.2012.09.096 DOI:10.1016/j.tet.2012.09.096