10-((5-bromo-1H-indol-3-yl)methylene)-7-(4-chlorophenyl)-3-methoxy-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9(6H)-one

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Chemical Name:10-((5-bromo-1H-indol-3-yl)methylene)-7-(4-chlorophenyl)-3-methoxy-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9(6H)-one
CAS No.:1628075-44-4
Molecular Formula:C₃₀H₂₁BrClN₃O₂S
Molecular Weight:602.939
Hs Code.:

Synonyms:10-((5-bromo-1H-indol-3-yl)methylene)-7-(4-chlorophenyl)-3-methoxy-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9(6H)-one

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Chemical Property of 10-((5-bromo-1H-indol-3-yl)methylene)-7-(4-chlorophenyl)-3-methoxy-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9(6H)-one

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Technology Process of 10-((5-bromo-1H-indol-3-yl)methylene)-7-(4-chlorophenyl)-3-methoxy-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9(6H)-one

There total 4 articles about 10-((5-bromo-1H-indol-3-yl)methylene)-7-(4-chlorophenyl)-3-methoxy-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9(6H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 877-03-2
5-bromo-1H-indole-3-carboxaldehyde

: 1628075-61-5
C₂₁H₁₇ClN₂O₂S

: 1628075-44-4
10-((5-bromo-1H-indol-3-yl)methylene)-7-(4-chlorophenyl)-3-methoxy-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9(6H)-one

Guidance literature:: With piperidine; In ethanol; for 3h; Reflux;
DOI:10.1016/j.bmcl.2014.07.030

Reference yield:

: 104-88-1
4-chlorobenzaldehyde

: 1628075-44-4
10-((5-bromo-1H-indol-3-yl)methylene)-7-(4-chlorophenyl)-3-methoxy-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9(6H)-one

Guidance literature:: Multi-step reaction with 3 steps

1: poly(4-vinylpyridinium)hydrogen sulfate / neat (no solvent) / 120 °C

2: acetic acid / Reflux

3: piperidine / ethanol / 3 h / Reflux

With piperidine; acetic acid; In ethanol; 1: |Biginelli Pyrimidone Synthesis / 3: |Knoevenagel Condensation;
DOI:10.1016/j.bmcl.2014.07.030

Reference yield:

: 4-(4-chlorophenyl)-3,4,5,6-tetrahydro-8-methoxybenzo[h]quinazolin-2-(1H)-thione

: 1628075-44-4
10-((5-bromo-1H-indol-3-yl)methylene)-7-(4-chlorophenyl)-3-methoxy-7,10-dihydro-5H-benzo[h]thiazolo[2,3-b]quinazolin-9(6H)-one

Guidance literature:: Multi-step reaction with 2 steps

1: acetic acid / Reflux

2: piperidine / ethanol / 3 h / Reflux

With piperidine; acetic acid; In ethanol; 2: |Knoevenagel Condensation;
DOI:10.1016/j.bmcl.2014.07.030