1-Benzyloxymethyl-3-hydroxymethyl-1,4,6,7-tetrahydro-pyrrolo[2,3-c]pyridin-5-one

Base Information

Chemical Name:1-Benzyloxymethyl-3-hydroxymethyl-1,4,6,7-tetrahydro-pyrrolo[2,3-c]pyridin-5-one
CAS No.:191936-84-2
Molecular Formula:C₁₆H₁₈N₂O₃
Molecular Weight:286.331
Hs Code.:

Synonyms:1-Benzyloxymethyl-3-hydroxymethyl-1,4,6,7-tetrahydro-pyrrolo[2,3-c]pyridin-5-one

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Chemical Property of 1-Benzyloxymethyl-3-hydroxymethyl-1,4,6,7-tetrahydro-pyrrolo[2,3-c]pyridin-5-one

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Technology Process of 1-Benzyloxymethyl-3-hydroxymethyl-1,4,6,7-tetrahydro-pyrrolo[2,3-c]pyridin-5-one

There total 4 articles about 1-Benzyloxymethyl-3-hydroxymethyl-1,4,6,7-tetrahydro-pyrrolo[2,3-c]pyridin-5-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 191936-82-0
1-Benzyloxymethyl-5-oxo-4,5,6,7-tetrahydro-1H-pyrrolo[2,3-c]pyridine-3-carboxylic acid ethyl ester

: 191936-84-2
1-Benzyloxymethyl-3-hydroxymethyl-1,4,6,7-tetrahydro-pyrrolo[2,3-c]pyridin-5-one

Guidance literature:: With diisobutylaluminium hydride; In dichloromethane; toluene; for 0.5h;
DOI:10.1016/S0040-4020(97)00469-9

Reference yield:

: 184921-36-6
4-Ethoxycarbonylmethyl-5-(hydroxyimino-methyl)-1H-pyrrole-3-carboxylic acid ethyl ester

: 191936-84-2
1-Benzyloxymethyl-3-hydroxymethyl-1,4,6,7-tetrahydro-pyrrolo[2,3-c]pyridin-5-one

Guidance literature:: Multi-step reaction with 4 steps

1: H₂, 2 N HCl / Pd(OH)2-C / ethanol / 2 h / Ambient temperature

2: 474 mg / NaOEt / ethanol / 5 h / 40 °C

3: 1) NaH / 1) DMF, room temperature, 40 min, 2) DMF, 5 h

4: 65 percent / DIBAL / toluene; CH₂Cl₂ / 0.5 h

With hydrogenchloride; hydrogen; sodium ethanolate; sodium hydride; diisobutylaluminium hydride; palladium hydroxide - carbon; In ethanol; dichloromethane; toluene;
DOI:10.1016/S0040-4020(97)00469-9

Reference yield:

: 184921-37-7
5-Aminomethyl-4-ethoxycarbonylmethyl-1H-pyrrole-3-carboxylic acid ethyl ester

: 191936-84-2
1-Benzyloxymethyl-3-hydroxymethyl-1,4,6,7-tetrahydro-pyrrolo[2,3-c]pyridin-5-one

Guidance literature:: Multi-step reaction with 3 steps

1: 474 mg / NaOEt / ethanol / 5 h / 40 °C

2: 1) NaH / 1) DMF, room temperature, 40 min, 2) DMF, 5 h

3: 65 percent / DIBAL / toluene; CH₂Cl₂ / 0.5 h

With sodium ethanolate; sodium hydride; diisobutylaluminium hydride; In ethanol; dichloromethane; toluene;
DOI:10.1016/S0040-4020(97)00469-9