methyl 4,6-dideoxy-4-<<(2,4,6-trideoxy-3-O<(1,1-dimethylethyl)dimethylsilyl>-4-(methylthio)-β-D-ribo-hexopyranosyl)oxy><2-(trimethylsilyl)ethoxycarbonyl>amino>-2-O-<4-amino-2,4-dideoxy-3-O-methyl-α-L-threo-pentopyranosyl>-3-O-(4-methoxyphenyl)methyl..

Base Information

Chemical Name:methyl 4,6-dideoxy-4-<<(2,4,6-trideoxy-3-O<(1,1-dimethylethyl)dimethylsilyl>-4-(methylthio)-β-D-ribo-hexopyranosyl)oxy><2-(trimethylsilyl)ethoxycarbonyl>amino>-2-O-<4-amino-2,4-dideoxy-3-O-methyl-α-L-threo-pentopyranosyl>-3-O-(4-methoxyphenyl)methyl..
CAS No.:134262-87-6
Molecular Formula:C₄₀H₇₂N₂O₁₂SSi₂
Molecular Weight:861.255
Hs Code.:

methyl 4,6-dideoxy-4-<<(2,4,6-trideoxy-3-O<(1,1-dimethylethyl)dimethylsilyl>-4-(methylthio)-β-D-ribo-hexopyranosyl)oxy><2-(trimethylsilyl)ethoxycarbonyl>amino>-2-O-<4-amino-2,4-dideoxy-3-O-methyl-α-L-threo-pentopyranosyl>-3-O-(4-methoxyphenyl)methyl..

Synonyms:methyl 4,6-dideoxy-4-<<(2,4,6-trideoxy-3-O<(1,1-dimethylethyl)dimethylsilyl>-4-(methylthio)-β-D-ribo-hexopyranosyl)oxy><2-(trimethylsilyl)ethoxycarbonyl>amino>-2-O-<4-amino-2,4-dideoxy-3-O-methyl-α-L-threo-pentopyranosyl>-3-O-(4-methoxyphenyl)methyl..

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Chemical Property of methyl 4,6-dideoxy-4-<<(2,4,6-trideoxy-3-O<(1,1-dimethylethyl)dimethylsilyl>-4-(methylthio)-β-D-ribo-hexopyranosyl)oxy><2-(trimethylsilyl)ethoxycarbonyl>amino>-2-O-<4-amino-2,4-dideoxy-3-O-methyl-α-L-threo-pentopyranosyl>-3-O-(4-methoxyphenyl)methyl..

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Technology Process of methyl 4,6-dideoxy-4-<<(2,4,6-trideoxy-3-O<(1,1-dimethylethyl)dimethylsilyl>-4-(methylthio)-β-D-ribo-hexopyranosyl)oxy><2-(trimethylsilyl)ethoxycarbonyl>amino>-2-O-<4-amino-2,4-dideoxy-3-O-methyl-α-L-threo-pentopyranosyl>-3-O-(4-methoxyphenyl)methyl..

There total 33 articles about methyl 4,6-dideoxy-4-<<(2,4,6-trideoxy-3-O<(1,1-dimethylethyl)dimethylsilyl>-4-(methylthio)-β-D-ribo-hexopyranosyl)oxy><2-(trimethylsilyl)ethoxycarbonyl>amino>-2-O-<4-amino-2,4-dideoxy-3-O-methyl-α-L-threo-pentopyranosyl>-3-O-(4-methoxyphenyl)methyl.. which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 134262-77-4
methyl 4,6-dideoxy-4-<<(2,4,6-trideoxy-3-O<(1,1-dimethylethyl)dimethylsilyl>-4-(methylthio)-β-D-ribo-hexopyranosyl)oxy><2-(trimethylsilyl)ethoxycarbonyl>amino>-2-O-<2,4-dideoxy-3-O-methyl-4-phthalimido-α-L-threo-pentopyranosyl>-3-O-(4-methoxyphenyl)..

: 134262-87-6
methyl 4,6-dideoxy-4-<<(2,4,6-trideoxy-3-O<(1,1-dimethylethyl)dimethylsilyl>-4-(methylthio)-β-D-ribo-hexopyranosyl)oxy><2-(trimethylsilyl)ethoxycarbonyl>amino>-2-O-<4-amino-2,4-dideoxy-3-O-methyl-α-L-threo-pentopyranosyl>-3-O-(4-methoxyphenyl)methyl..

Guidance literature:: With hydrazine; In ethanol; for 0.25h; Heating;
DOI:10.1021/ja00126a013

Reference yield:

: 20160-60-5
2-(trimethylsilyl)-ethoxycarbonyl chloride

: 134262-87-6
methyl 4,6-dideoxy-4-<<(2,4,6-trideoxy-3-O<(1,1-dimethylethyl)dimethylsilyl>-4-(methylthio)-β-D-ribo-hexopyranosyl)oxy><2-(trimethylsilyl)ethoxycarbonyl>amino>-2-O-<4-amino-2,4-dideoxy-3-O-methyl-α-L-threo-pentopyranosyl>-3-O-(4-methoxyphenyl)methyl..

Guidance literature:: Multi-step reaction with 6 steps

1: 60 percent / NH₂OH*HCl, aq. NaOH / dioxane / 14 h

2: 52 percent / PH₃P*HBr / CH₂Cl₂ / 0.33 h / Ambient temperature

3: 98 percent / EtSH, K₂CO₃ / methanol / 0.33 h / Ambient temperature

4: DBU / benzene / 4 h / Ambient temperature

5: 1.) NaH / 1.) DMF, from o deg C to RT, 15 min, 2.) DMF, 0 deg C, 15 min

6: 87 percent / hydrazine / aq. ethanol / 0.25 h / Heating

With sodium hydroxide; hydroxylamine hydrochloride; triphenylphosphine hydrobromide; sodium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; ethanethiol; hydrazine; In 1,4-dioxane; methanol; ethanol; dichloromethane; benzene;
DOI:10.1021/ja00126a013

Reference yield:

: 69739-34-0
t-butyldimethylsiyl triflate

: 134262-87-6
methyl 4,6-dideoxy-4-<<(2,4,6-trideoxy-3-O<(1,1-dimethylethyl)dimethylsilyl>-4-(methylthio)-β-D-ribo-hexopyranosyl)oxy><2-(trimethylsilyl)ethoxycarbonyl>amino>-2-O-<4-amino-2,4-dideoxy-3-O-methyl-α-L-threo-pentopyranosyl>-3-O-(4-methoxyphenyl)methyl..

Guidance literature:: Multi-step reaction with 6 steps

1: 88 percent / pyridine / CH₂Cl₂ / 48 h / Ambient temperature

2: 52 percent / PH₃P*HBr / CH₂Cl₂ / 0.33 h / Ambient temperature

3: 98 percent / EtSH, K₂CO₃ / methanol / 0.33 h / Ambient temperature

4: DBU / benzene / 4 h / Ambient temperature

5: 1.) NaH / 1.) DMF, from o deg C to RT, 15 min, 2.) DMF, 0 deg C, 15 min

6: 87 percent / hydrazine / aq. ethanol / 0.25 h / Heating

With pyridine; triphenylphosphine hydrobromide; sodium hydride; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; ethanethiol; hydrazine; In methanol; ethanol; dichloromethane; benzene;
DOI:10.1021/ja00126a013